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Comparison of Analytical Methods of Brain [(18)F]FDG-PET after Severe Traumatic Brain Injury

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@article{19b97c517011487883e4f89b9379d064,
title = "Comparison of Analytical Methods of Brain [(18)F]FDG-PET after Severe Traumatic Brain Injury",
abstract = "BACKGROUND: Loss of consciousness has been shown to reduce cerebral metabolic rates of glucose (CMRglc) measured by brain [(18)F]FDG-PET. Measurements of regional metabolic patterns by normalization to global cerebral metabolism or cerebellum may underestimate widespread reductions.NEW METHOD: The aim of this study was to compare quantification methods of whole brain glucose metabolism, including whole brain [18F]FDG uptake normalized to uptake in cerebellum, normalized to injected activity, normalized to plasma tracer concentration, and two methods for estimating CMRglc. Six patients suffering from severe traumatic brain injury (TBI) and ten healthy controls (HC) underwent a 10min static [(18)F]FDG-PET scan and venous blood sampling.RESULTS: Except from normalizing to cerebellum, all quantification methods found significant lower level of whole brain glucose metabolism of 25-33{\%} in TBI patients compared to HC. In accordance these measurements correlated to level of consciousness.COMPARISON WITH EXISTING METHODS: Our study demonstrates that the analysis method of the [(18)F]FDG PET data has a substantial impact on the estimated whole brain cerebral glucose metabolism in patients with severe TBI. Importantly, the SUVR method which is often used in a clinical setting was not able to distinguish patients with severe TBI from HC at the whole-brain level.CONCLUSION: We recommend supplementing a static [(18)F]FDG scan with a single venous blood sample in future studies of patients with severe TBI or reduced level of consciousness. This can be used for simple semi-quantitative uptake values by normalizing brain activity uptake to plasma tracer concentration, or quantitative estimates of CMRglc.",
keywords = "Journal Article",
author = "Karine Madsen and Sara Hesby and Ingrid Poulsen and Stefan Fuglsang and Jesper Graff and Larsen, {Karen B} and Kammersgaard, {Lars P} and Ian Law and Siebner, {Hartwig R}",
note = "Copyright {\circledC} 2017. Published by Elsevier B.V.",
year = "2017",
month = "10",
day = "23",
doi = "10.1016/j.jneumeth.2017.07.032",
language = "English",
volume = "291",
pages = "176--181",
journal = "Journal of Neuroscience Methods",
issn = "0165-0270",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Comparison of Analytical Methods of Brain [(18)F]FDG-PET after Severe Traumatic Brain Injury

AU - Madsen, Karine

AU - Hesby, Sara

AU - Poulsen, Ingrid

AU - Fuglsang, Stefan

AU - Graff, Jesper

AU - Larsen, Karen B

AU - Kammersgaard, Lars P

AU - Law, Ian

AU - Siebner, Hartwig R

N1 - Copyright © 2017. Published by Elsevier B.V.

PY - 2017/10/23

Y1 - 2017/10/23

N2 - BACKGROUND: Loss of consciousness has been shown to reduce cerebral metabolic rates of glucose (CMRglc) measured by brain [(18)F]FDG-PET. Measurements of regional metabolic patterns by normalization to global cerebral metabolism or cerebellum may underestimate widespread reductions.NEW METHOD: The aim of this study was to compare quantification methods of whole brain glucose metabolism, including whole brain [18F]FDG uptake normalized to uptake in cerebellum, normalized to injected activity, normalized to plasma tracer concentration, and two methods for estimating CMRglc. Six patients suffering from severe traumatic brain injury (TBI) and ten healthy controls (HC) underwent a 10min static [(18)F]FDG-PET scan and venous blood sampling.RESULTS: Except from normalizing to cerebellum, all quantification methods found significant lower level of whole brain glucose metabolism of 25-33% in TBI patients compared to HC. In accordance these measurements correlated to level of consciousness.COMPARISON WITH EXISTING METHODS: Our study demonstrates that the analysis method of the [(18)F]FDG PET data has a substantial impact on the estimated whole brain cerebral glucose metabolism in patients with severe TBI. Importantly, the SUVR method which is often used in a clinical setting was not able to distinguish patients with severe TBI from HC at the whole-brain level.CONCLUSION: We recommend supplementing a static [(18)F]FDG scan with a single venous blood sample in future studies of patients with severe TBI or reduced level of consciousness. This can be used for simple semi-quantitative uptake values by normalizing brain activity uptake to plasma tracer concentration, or quantitative estimates of CMRglc.

AB - BACKGROUND: Loss of consciousness has been shown to reduce cerebral metabolic rates of glucose (CMRglc) measured by brain [(18)F]FDG-PET. Measurements of regional metabolic patterns by normalization to global cerebral metabolism or cerebellum may underestimate widespread reductions.NEW METHOD: The aim of this study was to compare quantification methods of whole brain glucose metabolism, including whole brain [18F]FDG uptake normalized to uptake in cerebellum, normalized to injected activity, normalized to plasma tracer concentration, and two methods for estimating CMRglc. Six patients suffering from severe traumatic brain injury (TBI) and ten healthy controls (HC) underwent a 10min static [(18)F]FDG-PET scan and venous blood sampling.RESULTS: Except from normalizing to cerebellum, all quantification methods found significant lower level of whole brain glucose metabolism of 25-33% in TBI patients compared to HC. In accordance these measurements correlated to level of consciousness.COMPARISON WITH EXISTING METHODS: Our study demonstrates that the analysis method of the [(18)F]FDG PET data has a substantial impact on the estimated whole brain cerebral glucose metabolism in patients with severe TBI. Importantly, the SUVR method which is often used in a clinical setting was not able to distinguish patients with severe TBI from HC at the whole-brain level.CONCLUSION: We recommend supplementing a static [(18)F]FDG scan with a single venous blood sample in future studies of patients with severe TBI or reduced level of consciousness. This can be used for simple semi-quantitative uptake values by normalizing brain activity uptake to plasma tracer concentration, or quantitative estimates of CMRglc.

KW - Journal Article

U2 - 10.1016/j.jneumeth.2017.07.032

DO - 10.1016/j.jneumeth.2017.07.032

M3 - Journal article

VL - 291

SP - 176

EP - 181

JO - Journal of Neuroscience Methods

JF - Journal of Neuroscience Methods

SN - 0165-0270

ER -

ID: 51565127