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Comparison of a dual-frequency bio-impedance analyser with dual-energy X-ray absorptiometry for assessment of body composition in geriatric patients

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BACKGROUND AND OBJECTIVES: Measuring body composition is relevant in geriatric medical patients at high risk of sarcopenia (loss of muscle mass/strength) for diagnosis and monitoring efficacy of treatment interventions. Dual-energy X-ray absorptiometry (DXA) and bio-impedance analysis (BIA) are widely used in research/clinical practices, but their agreement is unknown in this population. Therefore, it was investigated how a dual-frequency (DF)-BIA compares to DXA regarding replicability, direct comparisons and monitoring of total/segmental body composition in geriatric medical patients.

METHODS: Measurements were taken while admitted to the geriatric medical ward and repeated 12 weeks after discharge for monitoring. Total population and gender-specific analyses were made.

RESULTS: Thirty-one participants were included (age: 82 ± 6 years, BMI: 26.2 ± 4.3), and ten lost to follow-up. Replicability was high for both methods (R2 ; 0.956, 0.999, p < .0001, n = 31), however, with wide 5th-95th percentile ranges for individual agreement. Bland-Altman plots revealed significant fixed systematic and negative proportional biases for body composition variables-both for the direct comparisons (e.g., total LBM, 1.2 kg higher with DF-BIA, p < .05, n = 31) and for monitoring (total LBM, kg; men [n = 15]: DXA [0.96 ± 2.61] vs. DF-BIA [-0.35 ± 3.52] and women [n = 16]: DXA [-0.39 ± 1.51] vs. DF-BIA [-1.05 ± 2.24]). Generally, correlations for direct comparisons were higher than for monitoring (R2 ; 0.870, 0.947 vs. 0.048, 0.717 [head region not included], n = 31).

CONCLUSION: DF-BIA and DXA cannot be used interchangeably in geriatric medical patients. However, high replicability shows that both methods may be used for monitoring under standardized conditions. Results indicate gender-specific differences, and segmental analysis can only be recommended with DXA using clear anatomical references.

OriginalsprogEngelsk
TidsskriftClinical Physiology and Functional Imaging
Vol/bind40
Udgave nummer4
Sider (fra-til)290-301
Antal sider12
ISSN1475-0961
DOI
StatusUdgivet - jul. 2020

Bibliografisk note

© 2020 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

ID: 61946874