Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Comparative electrophysiological, functional, and histological studies of nerve lesions in rats

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Local heparin is superior to systemic heparin in preventing arterial thrombosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Local application of FFR-rFVIIa reduces thrombus formation at arterial anastomosis in rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Long-term survival and recurrence after resection of bronchopulmonary carcinoids: A single-center cohort study of 236 patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Intravenous arylsulfatase A in metachromatic leukodystrophy: a phase 1/2 study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
The aim of this study was to establish a nerve lesion model to compare serial electrophysiological and functional outcome measures with histological findings. The relative significance of the parameters in lesions of diverse severity, the time course of recovery, and the tools for serial longitudinal studies after nerve lesions were studied in rats. We compared weekly electrophysiological and functional studies for 100 or 150 days in rats after crush or section/suture of the sciatic nerve at midthigh level. Finally, tibial nerves were taken for histology. We confirmed that recovery was faster and more complete in nerves regenerating after crush than after section, irrespective of method of evaluation. Furthermore, continuous maturational changes occurred in control nerves, and such continuous growth-related changes should be taken into account when evaluating maturational changes during nerve regeneration. A lack of correlation between evaluation methods supports that functional, morphological, and physiological parameters show different aspects of the recovery process after nerve lesions, and that these outcome measures should be included separately in therapeutic studies.
OriginalsprogEngelsk
TidsskriftMicrosurgery
Vol/bind25
Udgave nummer6
Sider (fra-til)508-19
Antal sider12
ISSN0738-1085
DOI
StatusUdgivet - 2005

ID: 36747426