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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

COMPARATIVE EFFECTIVENESS OF PROTON BEAM VERSUS PHOTODYNAMIC THERAPY TO SPARE THE VISION IN CIRCUMSCRIBED CHOROIDAL HEMANGIOMA

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  • Thibaud Mathis
  • Célia Maschi
  • Carlo Mosci
  • Charlotte A Espensen
  • Laurence Rosier
  • Catherine Favard
  • Sarah Tick
  • Charles-Henry Remignon
  • Paolo Ligorio
  • Nicolas Bonin
  • Joël Gambrelle
  • Anh-Minh Nguyen
  • Carsten Faber
  • Laurent Meyer
  • Frederic Mouriaux
  • Joël Herault
  • Stéphanie Baillif
  • Jens-Folke Kiilgaard
  • Laurent Kodjikian
  • Jean-Pierre Caujolle
  • Julia Salleron
  • Juliette Thariat
Vis graf over relationer

PURPOSE: The aim of this study was to compare the functional and anatomical effectiveness of photodynamic therapy (PDT) versus proton beam therapy (PBT) in a real-life setting for the treatment of circumscribed choroidal hemangioma.

METHODS: A total of 191 patients with a diagnosis of circumscribed choroidal hemangioma and treated by PBT or PDT were included for analyses.

RESULTS: The 119 patients (62.3%) treated by PDT were compared with the 72 patients treated by PBT. The final best-corrected visual acuity did not differ significantly between the two groups (P = 0.932) and final thickness was lower in the PBT compared with the PDT group (P = 0.001). None of the patients treated by PBT needed second-line therapy. In comparison, 53 patients (44.5%) initially treated by PDT required at least one other therapy and were associated with worse final best-corrected visual acuity (P = 0.037). In multivariate analysis, only an initial thickness greater than 3 mm remained significant (P = 0.01) to predict PDT failure with an estimated odds ratio of 2.72, 95% confidence interval (1.25-5.89).

CONCLUSION: Photodynamic therapy and PBT provide similar anatomical and functional outcomes for circumscribed choroidal hemangioma ≤3 mm, although multiple sessions are sometimes required for PDT. For tumors >3 mm, PBT seems preferable because it can treat the tumor in only 1 session with better functional and anatomical outcomes.

OriginalsprogEngelsk
TidsskriftRetina (Philadelphia, Pa.)
ISSN0275-004X
DOI
StatusE-pub ahead of print - 12 maj 2020

ID: 59853101