Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Dokumenter

DOI

  1. Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Interactions in multispecies biofilms: do they actually matter?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The in vivo biofilm

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Genome Sequence of an Unknown Subtype of Hepatitis C Virus Genotype 6: Another Piece for the Taxonomic Puzzle

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Genetic recombination is an important evolutionary mechanism for RNA viruses. The significance of this phenomenon for hepatitis C virus (HCV) has recently become evident, with the identification of circulating recombinant forms in HCV-infected individuals and by novel data from studies permitted by advances in HCV cell culture systems and genotyping protocols. HCV is readily able to produce viable recombinants, using replicative and non-replicative molecular mechanisms. However, our knowledge of the required molecular mechanisms remains limited. Understanding how HCV recombines might be instrumental for a better monitoring of global epidemiology, to clarify the virus evolution, and evaluate the impact of recombinant forms on the efficacy of oncoming combination drug therapies. For the latter, frequency and location of recombination events could affect the efficacy of multidrug regimens. This review will focus on current data available on HCV recombination, also in relation to more detailed data from other RNA viruses.

OriginalsprogEngelsk
TidsskriftTrends in Microbiology
Vol/bind22
Udgave nummer6
Sider (fra-til)354–364
ISSN0966-842X
DOI
StatusUdgivet - 10 mar. 2014

Mest downloadede publikationer

Ingen data tilgængelig

ID: 43813418