Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

Lena Sønder Snogdal; Mette Wod; Niels Grarup; Marie Aare Vestmar; Thomas Hempel Sparsø; T Jørgensen; Torsten Lauritzen; Henning Beck-Nielsen; J E Henriksen; O Pedersen; T Hansen; K Højlund

doi:10.1007/s00125-011-2377-0

Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

Lena Sønder Snogdal
, Mette Wod
, Niels Grarup
, Marie Aare Vestmar
, Thomas Hempel Sparsø
, T Jørgensen
, Torsten Lauritzen
, Henning Beck-Nielsen
, J E Henriksen
, O Pedersen
, T Hansen
, K Højlund

7 Citationer (Scopus)

Abstract

There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common variation in genes involved in oxidative phosphorylation (OxPhos) contributes to type 2 diabetes susceptibility or influences diabetes-related metabolic traits.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	55
Udgave nummer	2
Sider (fra-til)	340-8
Antal sider	9
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-011-2377-0
Status	Udgivet - 2012

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10.1007/s00125-011-2377-0

Citationsformater

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title = "Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes",

abstract = "There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common variation in genes involved in oxidative phosphorylation (OxPhos) contributes to type 2 diabetes susceptibility or influences diabetes-related metabolic traits.",

author = "Snogdal, \{Lena S{\o}nder\} and Mette Wod and Niels Grarup and Vestmar, \{Marie Aare\} and Spars{\o}, \{Thomas Hempel\} and T J{\o}rgensen and Torsten Lauritzen and Henning Beck-Nielsen and Henriksen, \{J E\} and O Pedersen and T Hansen and K H{\o}jlund",

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doi = "10.1007/s00125-011-2377-0",

language = "English",

volume = "55",

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TY - JOUR

T1 - Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

AU - Snogdal, Lena Sønder

AU - Wod, Mette

AU - Grarup, Niels

AU - Vestmar, Marie Aare

AU - Sparsø, Thomas Hempel

AU - Jørgensen, T

AU - Lauritzen, Torsten

AU - Beck-Nielsen, Henning

AU - Henriksen, J E

AU - Pedersen, O

AU - Hansen, T

AU - Højlund, K

PY - 2012

Y1 - 2012

N2 - There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common variation in genes involved in oxidative phosphorylation (OxPhos) contributes to type 2 diabetes susceptibility or influences diabetes-related metabolic traits.

AB - There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common variation in genes involved in oxidative phosphorylation (OxPhos) contributes to type 2 diabetes susceptibility or influences diabetes-related metabolic traits.

U2 - 10.1007/s00125-011-2377-0

DO - 10.1007/s00125-011-2377-0

M3 - Journal article

C2 - 22095239

SN - 0012-186X

VL - 55

SP - 340

EP - 348

JO - Diabetologia

JF - Diabetologia

IS - 2

ER -

Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

Abstract

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