Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Gormley, P, Kurki, MI, Hiekkala, ME, Veerapen, K, Häppölä, P, Mitchell, AA, Lal, D, Palta, P, Surakka, I, Kaunisto, MA, Hämäläinen, E, Vepsäläinen, S, Havanka, H, Harno, H, Ilmavirta, M, Nissilä, M, Säkö, E, Sumelahti, ML, Liukkonen, J, Sillanpää, M, Metsähonkala, L, Koskinen, S, Lehtimäki, T, Raitakari, O, Männikkö, M, Ran, C, Belin, AC, Jousilahti, P, Anttila, V, Salomaa, V, Artto, V, Färkkilä, M, Agee, M, Alipanahi, B, Auton, A, Bell, RK, Bryc, K, Elson, SL, Fontanillas, P, Furlotte, NA, Huber, KE, Kleinman, A, Litterman, NK, McCreight, JC, McIntyre, MH, Christensen, AF, Esserlind, AL, Hansen, TF, Ingason, A, Olesen, J, 23andMe Research Team & International Headache Genetics Consortium (IHGC) 2018, 'Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families' Neuron, bind 98, nr. 4, s. 743-753.e4. https://doi.org/10.1016/j.neuron.2018.04.014

APA

Gormley, P., Kurki, M. I., Hiekkala, M. E., Veerapen, K., Häppölä, P., Mitchell, A. A., ... International Headache Genetics Consortium (IHGC) (2018). Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron, 98(4), 743-753.e4. https://doi.org/10.1016/j.neuron.2018.04.014

CBE

Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA, Lal D, Palta P, Surakka I, Kaunisto MA, Hämäläinen E, Vepsäläinen S, Havanka H, Harno H, Ilmavirta M, Nissilä M, Säkö E, Sumelahti ML, Liukkonen J, Sillanpää M, Metsähonkala L, Koskinen S, Lehtimäki T, Raitakari O, Männikkö M, Ran C, Belin AC, Jousilahti P, Anttila V, Salomaa V, Artto V, Färkkilä M, Agee M, Alipanahi B, Auton A, Bell RK, Bryc K, Elson SL, Fontanillas P, Furlotte NA, Huber KE, Kleinman A, Litterman NK, McCreight JC, McIntyre MH, Christensen AF, Esserlind AL, Hansen TF, Ingason A, Olesen J, 23andMe Research Team, International Headache Genetics Consortium (IHGC). 2018. Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron. 98(4):743-753.e4. https://doi.org/10.1016/j.neuron.2018.04.014

MLA

Vancouver

Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA o.a. Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron. 2018 maj 16;98(4):743-753.e4. https://doi.org/10.1016/j.neuron.2018.04.014

Author

Gormley, Padhraig ; Kurki, Mitja I. ; Hiekkala, Marjo Eveliina ; Veerapen, Kumar ; Häppölä, Paavo ; Mitchell, Adele A. ; Lal, Dennis ; Palta, Priit ; Surakka, Ida ; Kaunisto, Mari Anneli ; Hämäläinen, Eija ; Vepsäläinen, Salli ; Havanka, Hannele ; Harno, Hanna ; Ilmavirta, Matti ; Nissilä, Markku ; Säkö, Erkki ; Sumelahti, Marja Liisa ; Liukkonen, Jarmo ; Sillanpää, Matti ; Metsähonkala, Liisa ; Koskinen, Seppo ; Lehtimäki, Terho ; Raitakari, Olli ; Männikkö, Minna ; Ran, Caroline ; Belin, Andrea Carmine ; Jousilahti, Pekka ; Anttila, Verneri ; Salomaa, Veikko ; Artto, Ville ; Färkkilä, Markus ; Agee, Michelle ; Alipanahi, Babak ; Auton, Adam ; Bell, Robert K. ; Bryc, Katarzyna ; Elson, Sarah L. ; Fontanillas, Pierre ; Furlotte, Nicholas A. ; Huber, Karen E. ; Kleinman, Aaron ; Litterman, Nadia K. ; McCreight, Jennifer C. ; McIntyre, Matthew H. ; Christensen, Anne Francke ; Esserlind, Ann Louise ; Hansen, Thomas Folkmann ; Ingason, Andres ; Olesen, Jes ; 23andMe Research Team ; International Headache Genetics Consortium (IHGC). / Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. I: Neuron. 2018 ; Bind 98, Nr. 4. s. 743-753.e4.

Bibtex

@article{a6e9975e41314fd0addf8fa094a4beb3,
title = "Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families",
abstract = "Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small effect, or a combination of the two hypotheses. In 8,319 individuals across 1,589 migraine families, we calculated migraine polygenic risk scores (PRS) and found a significantly higher common variant burden in familial cases (n = 5,317, OR = 1.76, 95{\%} CI = 1.71–1.81, p = 1.7 × 10−109) compared to population cases from the FINRISK cohort (n = 1,101, OR = 1.32, 95{\%} CI = 1.25–1.38, p = 7.2 × 10−17). The PRS explained 1.6{\%} of the phenotypic variance in the population cases and 3.5{\%} in the familial cases (including 2.9{\%} for migraine without aura, 5.5{\%} for migraine with typical aura, and 8.2{\%} for hemiplegic migraine). The results demonstrate a significant contribution of common polygenic variation to the familial aggregation of migraine. Gormley et al. use polygenic risk scores to show that common variation, captured by genome-wide association studies, in combination contributes to the aggregation of migraine in families. The results may have similar implications for other complex traits in general.",
keywords = "disease aggregation, familial aggregation, families, genome-wide association study, GWAS, hemiplegic migraine, migraine, migraine with aura, polygenic risk score, PRS",
author = "Padhraig Gormley and Kurki, {Mitja I.} and Hiekkala, {Marjo Eveliina} and Kumar Veerapen and Paavo H{\"a}pp{\"o}l{\"a} and Mitchell, {Adele A.} and Dennis Lal and Priit Palta and Ida Surakka and Kaunisto, {Mari Anneli} and Eija H{\"a}m{\"a}l{\"a}inen and Salli Veps{\"a}l{\"a}inen and Hannele Havanka and Hanna Harno and Matti Ilmavirta and Markku Nissil{\"a} and Erkki S{\"a}k{\"o} and Sumelahti, {Marja Liisa} and Jarmo Liukkonen and Matti Sillanp{\"a}{\"a} and Liisa Mets{\"a}honkala and Seppo Koskinen and Terho Lehtim{\"a}ki and Olli Raitakari and Minna M{\"a}nnikk{\"o} and Caroline Ran and Belin, {Andrea Carmine} and Pekka Jousilahti and Verneri Anttila and Veikko Salomaa and Ville Artto and Markus F{\"a}rkkil{\"a} and Michelle Agee and Babak Alipanahi and Adam Auton and Bell, {Robert K.} and Katarzyna Bryc and Elson, {Sarah L.} and Pierre Fontanillas and Furlotte, {Nicholas A.} and Huber, {Karen E.} and Aaron Kleinman and Litterman, {Nadia K.} and McCreight, {Jennifer C.} and McIntyre, {Matthew H.} and Christensen, {Anne Francke} and Esserlind, {Ann Louise} and Hansen, {Thomas Folkmann} and Andres Ingason and Jes Olesen and {23andMe Research Team} and {International Headache Genetics Consortium (IHGC)}",
year = "2018",
month = "5",
day = "16",
doi = "10.1016/j.neuron.2018.04.014",
language = "English",
volume = "98",
pages = "743--753.e4",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families

AU - Gormley, Padhraig

AU - Kurki, Mitja I.

AU - Hiekkala, Marjo Eveliina

AU - Veerapen, Kumar

AU - Häppölä, Paavo

AU - Mitchell, Adele A.

AU - Lal, Dennis

AU - Palta, Priit

AU - Surakka, Ida

AU - Kaunisto, Mari Anneli

AU - Hämäläinen, Eija

AU - Vepsäläinen, Salli

AU - Havanka, Hannele

AU - Harno, Hanna

AU - Ilmavirta, Matti

AU - Nissilä, Markku

AU - Säkö, Erkki

AU - Sumelahti, Marja Liisa

AU - Liukkonen, Jarmo

AU - Sillanpää, Matti

AU - Metsähonkala, Liisa

AU - Koskinen, Seppo

AU - Lehtimäki, Terho

AU - Raitakari, Olli

AU - Männikkö, Minna

AU - Ran, Caroline

AU - Belin, Andrea Carmine

AU - Jousilahti, Pekka

AU - Anttila, Verneri

AU - Salomaa, Veikko

AU - Artto, Ville

AU - Färkkilä, Markus

AU - Agee, Michelle

AU - Alipanahi, Babak

AU - Auton, Adam

AU - Bell, Robert K.

AU - Bryc, Katarzyna

AU - Elson, Sarah L.

AU - Fontanillas, Pierre

AU - Furlotte, Nicholas A.

AU - Huber, Karen E.

AU - Kleinman, Aaron

AU - Litterman, Nadia K.

AU - McCreight, Jennifer C.

AU - McIntyre, Matthew H.

AU - Christensen, Anne Francke

AU - Esserlind, Ann Louise

AU - Hansen, Thomas Folkmann

AU - Ingason, Andres

AU - Olesen, Jes

AU - 23andMe Research Team

AU - International Headache Genetics Consortium (IHGC)

PY - 2018/5/16

Y1 - 2018/5/16

N2 - Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small effect, or a combination of the two hypotheses. In 8,319 individuals across 1,589 migraine families, we calculated migraine polygenic risk scores (PRS) and found a significantly higher common variant burden in familial cases (n = 5,317, OR = 1.76, 95% CI = 1.71–1.81, p = 1.7 × 10−109) compared to population cases from the FINRISK cohort (n = 1,101, OR = 1.32, 95% CI = 1.25–1.38, p = 7.2 × 10−17). The PRS explained 1.6% of the phenotypic variance in the population cases and 3.5% in the familial cases (including 2.9% for migraine without aura, 5.5% for migraine with typical aura, and 8.2% for hemiplegic migraine). The results demonstrate a significant contribution of common polygenic variation to the familial aggregation of migraine. Gormley et al. use polygenic risk scores to show that common variation, captured by genome-wide association studies, in combination contributes to the aggregation of migraine in families. The results may have similar implications for other complex traits in general.

AB - Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small effect, or a combination of the two hypotheses. In 8,319 individuals across 1,589 migraine families, we calculated migraine polygenic risk scores (PRS) and found a significantly higher common variant burden in familial cases (n = 5,317, OR = 1.76, 95% CI = 1.71–1.81, p = 1.7 × 10−109) compared to population cases from the FINRISK cohort (n = 1,101, OR = 1.32, 95% CI = 1.25–1.38, p = 7.2 × 10−17). The PRS explained 1.6% of the phenotypic variance in the population cases and 3.5% in the familial cases (including 2.9% for migraine without aura, 5.5% for migraine with typical aura, and 8.2% for hemiplegic migraine). The results demonstrate a significant contribution of common polygenic variation to the familial aggregation of migraine. Gormley et al. use polygenic risk scores to show that common variation, captured by genome-wide association studies, in combination contributes to the aggregation of migraine in families. The results may have similar implications for other complex traits in general.

KW - disease aggregation

KW - familial aggregation

KW - families

KW - genome-wide association study

KW - GWAS

KW - hemiplegic migraine

KW - migraine

KW - migraine with aura

KW - polygenic risk score

KW - PRS

UR - http://www.scopus.com/inward/record.url?scp=85046116467&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2018.04.014

DO - 10.1016/j.neuron.2018.04.014

M3 - Journal article

VL - 98

SP - 743-753.e4

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 4

ER -

ID: 55288910