Common variant at 16p11.2 conferring risk of psychosis

S Steinberg; S de Jong; M Mattheisen; J Costas; Ditte Demontis; S Jamain; O P H Pietiläinen; Katie Lin; S Papiol; J Huttenlocher; Eythor Sigurdsson; E Vassos; I Giegling; R Breuer; G Fraser; N Walker; I Melle; S Djurovic; I Agartz; A Tuulio-Henriksson; J Suvisaari; J Lönnqvist; T Paunio; L Olsen; Thomas Folkmann Hansen; A Ingason; M Pirinen; E Strengman; D M Hougaard; T Orntoft; M Didriksen; Mads Vilhelm Hollegaard; M Nordentoft; L Abramova; V Kaleda; M Arrojo; J Sanjuán; C Arango; B Etain; F Bellivier; A Méary; F Schürhoff; A Szoke; M Ribolsi; V Magni; A Siracusano; S Sperling; M Rossner; C Christiansen; T Werge; GROUP

doi:10.1038/mp.2012.157

Common variant at 16p11.2 conferring risk of psychosis

S Steinberg, S de Jong, M Mattheisen, J Costas, Ditte Demontis, S Jamain, O P H Pietiläinen, Katie Lin, S Papiol, J Huttenlocher, Eythor Sigurdsson, E Vassos, I Giegling, R Breuer, G Fraser, N Walker, I Melle, S Djurovic, I Agartz, A Tuulio-HenrikssonJ Suvisaari, J Lönnqvist, T Paunio, L Olsen, Thomas Folkmann Hansen, A Ingason, M Pirinen, E Strengman, D M Hougaard, T Orntoft, M Didriksen, Mads Vilhelm Hollegaard, M Nordentoft, L Abramova, V Kaleda, M Arrojo, J Sanjuán, C Arango, B Etain, F Bellivier, A Méary, F Schürhoff, A Szoke, M Ribolsi, V Magni, A Siracusano, S Sperling, M Rossner, C Christiansen, T Werge, GROUP

79 Citationer (Scopus)

Abstract

Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).Molecular Psychiatry advance online publication, 20 November 2012; doi:10.1038/mp.2012.157.

Originalsprog	Engelsk
Tidsskrift	Molecular Psychiatry
Vol/bind	19
Sider (fra-til)	108–114
ISSN	1359-4184
DOI	https://doi.org/10.1038/mp.2012.157
Status	Udgivet - 2014

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10.1038/mp.2012.157

Citationsformater

Steinberg, S., de Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., Pietiläinen, O. P. H., Lin, K., Papiol, S., Huttenlocher, J., Sigurdsson, E., Vassos, E., Giegling, I., Breuer, R., Fraser, G., Walker, N., Melle, I., Djurovic, S., Agartz, I., ... GROUP (2014). Common variant at 16p11.2 conferring risk of psychosis. Molecular Psychiatry, 19, 108–114. https://doi.org/10.1038/mp.2012.157

Steinberg, S, de Jong, S, Mattheisen, M, Costas, J, Demontis, D, Jamain, S, Pietiläinen, OPH, Lin, K, Papiol, S, Huttenlocher, J, Sigurdsson, E, Vassos, E, Giegling, I, Breuer, R, Fraser, G, Walker, N, Melle, I, Djurovic, S, Agartz, I, Tuulio-Henriksson, A, Suvisaari, J, Lönnqvist, J, Paunio, T, Olsen, L, Hansen, TF , Ingason, A, Pirinen, M, Strengman, E, Hougaard, DM, Orntoft, T, Didriksen, M, Hollegaard, MV, Nordentoft, M, Abramova, L, Kaleda, V, Arrojo, M, Sanjuán, J, Arango, C, Etain, B, Bellivier, F, Méary, A, Schürhoff, F, Szoke, A, Ribolsi, M, Magni, V, Siracusano, A, Sperling, S, Rossner, M, Christiansen, C, Werge, T & GROUP 2014, 'Common variant at 16p11.2 conferring risk of psychosis', Molecular Psychiatry, bind 19, s. 108–114. https://doi.org/10.1038/mp.2012.157

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title = "Common variant at 16p11.2 conferring risk of psychosis",

abstract = "Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).Molecular Psychiatry advance online publication, 20 November 2012; doi:10.1038/mp.2012.157.",

author = "S Steinberg and {de Jong}, S and M Mattheisen and J Costas and Ditte Demontis and S Jamain and Pietil{\"a}inen, {O P H} and Katie Lin and S Papiol and J Huttenlocher and Eythor Sigurdsson and E Vassos and I Giegling and R Breuer and G Fraser and N Walker and I Melle and S Djurovic and I Agartz and A Tuulio-Henriksson and J Suvisaari and J L{\"o}nnqvist and T Paunio and L Olsen and Hansen, {Thomas Folkmann} and A Ingason and M Pirinen and E Strengman and Hougaard, {D M} and T Orntoft and M Didriksen and Hollegaard, {Mads Vilhelm} and M Nordentoft and L Abramova and V Kaleda and M Arrojo and J Sanju{\'a}n and C Arango and B Etain and F Bellivier and A M{\'e}ary and F Sch{\"u}rhoff and A Szoke and M Ribolsi and V Magni and A Siracusano and S Sperling and M Rossner and C Christiansen and T Werge and GROUP",

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T1 - Common variant at 16p11.2 conferring risk of psychosis

AU - Steinberg, S

AU - de Jong, S

AU - Mattheisen, M

AU - Costas, J

AU - Demontis, Ditte

AU - Jamain, S

AU - Pietiläinen, O P H

AU - Lin, Katie

AU - Papiol, S

AU - Huttenlocher, J

AU - Sigurdsson, Eythor

AU - Vassos, E

AU - Giegling, I

AU - Breuer, R

AU - Fraser, G

AU - Walker, N

AU - Melle, I

AU - Djurovic, S

AU - Agartz, I

AU - Tuulio-Henriksson, A

AU - Suvisaari, J

AU - Lönnqvist, J

AU - Paunio, T

AU - Olsen, L

AU - Hansen, Thomas Folkmann

AU - Ingason, A

AU - Pirinen, M

AU - Strengman, E

AU - Hougaard, D M

AU - Orntoft, T

AU - Didriksen, M

AU - Hollegaard, Mads Vilhelm

AU - Nordentoft, M

AU - Abramova, L

AU - Kaleda, V

AU - Arrojo, M

AU - Sanjuán, J

AU - Arango, C

AU - Etain, B

AU - Bellivier, F

AU - Méary, A

AU - Schürhoff, F

AU - Szoke, A

AU - Ribolsi, M

AU - Magni, V

AU - Siracusano, A

AU - Sperling, S

AU - Rossner, M

AU - Christiansen, C

AU - Werge, T

AU - GROUP

N1 - (2014) 19, 108–114

PY - 2014

Y1 - 2014

N2 - Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).Molecular Psychiatry advance online publication, 20 November 2012; doi:10.1038/mp.2012.157.

AB - Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).Molecular Psychiatry advance online publication, 20 November 2012; doi:10.1038/mp.2012.157.

U2 - 10.1038/mp.2012.157

DO - 10.1038/mp.2012.157

M3 - Journal article

C2 - 23164818

VL - 19

SP - 108

EP - 114

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

ER -

Common variant at 16p11.2 conferring risk of psychosis

Abstract

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