Commentary on two recently published formal guidelines on management of "mosaic" embryos after preimplantation genetic testing for aneuploidy (PGT-A)

Norbert Gleicher, David H Barad, Zion Ben-Rafael, Demian Glujovsky, Lyka Mochizuki, Deepak Modi, Maximillian Murtinger, Pasquale Patrizio, Raoul Orvieto, Shizuko Takahashi, Andrea Weghofer, Søren Ziebe, International Do No Harm Group in IVF (IDNHG-IVF)

    12 Citationer (Scopus)

    Abstract

    Two professional societies recently published opinions on the clinical management of "mosaic" results from preimplantation genetic testing for aneuploidy (PGT-A) in human blastocyst-stage embryos in associations with in vitro fertilization (IVF). We here point out three principal shortcomings: (i) Though a most recent societal opinion states that it should not be understood as an endorsement of the use of PGT-A, any discussion of how PGT-A should be clinically interpreted for all practical purposes does offer such an endorsement. (ii) The same guideline derived much of its opinion from a preceding guidance in favor of utilization of PGT-A that did not follow even minimal professional requirements for establishment of practice guidelines. (iii) Published guidelines on so-called "mosaic" embryos from both societies contradict basic biological characteristics of human preimplantation-stage embryos. They, furthermore, are clinically unvalidated and interpret results of a test, increasingly seen as harmful to IVF outcomes for many infertile women. Qualified professional organizations, therefore, should finally offer transparent guidelines about the utilization of PGT-A in association with IVF in general.

    OriginalsprogEngelsk
    Artikelnummer23
    TidsskriftReproductive Biology and Endocrinology
    Vol/bind19
    Udgave nummer1
    Sider (fra-til)23
    ISSN1477-7827
    DOI
    StatusUdgivet - 18 feb. 2021

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