Combination of autoantibodies against different histone proteins influences complement-dependent phagocytosis of necrotic cell material by polymorphonuclear leukocytes in systemic lupus erythematosus

Birgitta Gullstrand, Malin H Lefort, Helena Tydén, Andreas Jönsen, Christian Lood, Asa Johansson, Søren Jacobsen, Lennart Truedsson, Anders A Bengtsson

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    Abstract

    Polymorphonuclear leukocytes (PMN) with autoantibody-coated engulfed necrotic cell material (NC) are frequently seen in systemic lupus erythematosus (SLE). We evaluated the roles of complement, different antihistone antibodies (anti-H ab), and oxidative burst in the phagocytosis of NC by PMN, as well as association to disease activity and clinical phenotype in SLE.
    OriginalsprogEngelsk
    TidsskriftJournal of Rheumatology
    Vol/bind39
    Udgave nummer8
    Sider (fra-til)1619-27
    Antal sider9
    ISSN0315-162X
    DOI
    StatusUdgivet - 2012

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