Combating biofilms

Liang Yang, Yang Liu, Hong Wu, Zhijun Song, Niels Høiby, Søren Molin, Michael Christian Givskov

166 Citationer (Scopus)

Abstract

Biofilms are complex microbial communities consisting of microcolonies embedded in a matrix of self-produced polymer substances. Biofilm cells show much greater resistance to environmental challenges including antimicrobial agents than their free-living counterparts. The biofilm mode of life is believed to significantly contribute to successful microbial survival in hostile environments. Conventional treatment, disinfection and cleaning strategies do not proficiently deal with biofilm-related problems, such as persistent infections and contamination of food production facilities. In this review, strategies to control biofilms are discussed, including those of inhibition of microbial attachment, interference of biofilm structure development and differentiation, killing of biofilm cells and induction of biofilm dispersion.
OriginalsprogEngelsk
TidsskriftF E M S Immunology and Medical Microbiology
Vol/bind65
Udgave nummer2
Sider (fra-til)145-57
Antal sider12
ISSN0928-8244
DOI
StatusUdgivet - 2012

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