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Collagen VI Contains Multiple Host Defense Peptides with Potent In Vivo Activity

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  • Suado M Abdillahi
  • Tobias Maaß
  • Gopinath Kasetty
  • Adam A Strömstedt
  • Maria Baumgarten
  • Ramesh Tati
  • Sara L Nordin
  • Björn Walse
  • Raimund Wagener
  • Artur Schmidtchen
  • Matthias Mörgelin
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Collagen VI is a ubiquitous extracellular matrix component that forms extensive microfibrillar networks in most connective tissues. In this study, we describe for the first time, to our knowledge, that the collagen VI von Willebrand factor type A-like domains exhibit a broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria in human skin infections in vivo. In silico sequence and structural analysis of VWA domains revealed that they contain cationic and amphipathic peptide sequence motifs, which might explain the antimicrobial nature of collagen VI. In vitro and in vivo studies show that these peptides exhibited significant antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa through membrane disruption. Our findings shed new light on the role of collagen VI-derived peptides in innate host defense and provide templates for development of peptide-based antibacterial therapies.

OriginalsprogEngelsk
TidsskriftJournal of immunology (Baltimore, Md. : 1950)
Vol/bind201
Udgave nummer3
Sider (fra-til)1007-1020
Antal sider14
ISSN0022-1767
DOI
StatusUdgivet - 1 aug. 2018

ID: 56331696