Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms

Eva Armengol, Kasper Nørskov Kragh, Tim Tolker-Nielsen, Josep M Sierra, Doaa Higazy, Oana Ciofu, Miguel Viñas, Niels Høiby*

*Corresponding author af dette arbejde
8 Citationer (Scopus)

Abstract

The emergence of multidrug-resistant Pseudomonas aeruginosa infections has urged the need to find new strategies, such as the use of combinations of antibiotics. Among these, the combination of colistin with other antibiotics has been studied. Here, the action of combinations of colistin and rifampicin on both planktonic and sessile cells of colistin-resistant P. aeruginosa was studied. Dynamic biofilms were formed and treated with such a combination, resulting in an active killing effect of both colistin-resistant and colistin-susceptible P. aeruginosa in biofilms. The results suggest that the action of colistin on the outer membrane facilitates rifampicin penetration, regardless of the colistin-resistant phenotype. Based on these in vitro data, we propose a colistin-rifampicin combination as a promising treatment for infections caused by colistin-resistant P. aeruginosa.

OriginalsprogEngelsk
TidsskriftAntimicrobial Agents and Chemotherapy
Vol/bind67
Udgave nummer4
Sider (fra-til)e0164122
Antal sider11
ISSN0066-4804
DOI
StatusUdgivet - 18 apr. 2023

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