Colchicine inhibits stimulated release of gastric histamine but not activation of histidine decarboxylase

R Håkanson, J F Rehfeld, G Liedberg, F Sundler

Abstract

In the rat, gastric mucosal histamine is mobilized and histidine decarboxylase activated by treatment with insulin or pentagastrin. Colchicine pretreatment prevented the histamine release without preventing the enzyme activation. The results suggest a) that histamine release and histidine decarboxylase activation are independent events, and b) that microtubules are involved in the release of histamine.

OriginalsprogEngelsk
TidsskriftExperientia
Vol/bind33
Udgave nummer3
Sider (fra-til)305-6
Antal sider2
ISSN0014-4754
DOI
StatusUdgivet - 15 mar. 1977
Udgivet eksterntJa

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