Colchicine inhibits stimulated release of gastric histamine but not activation of histidine decarboxylase

R Håkanson; J F Rehfeld; G Liedberg; F Sundler

doi:10.1007/BF02002794

Colchicine inhibits stimulated release of gastric histamine but not activation of histidine decarboxylase

R Håkanson, J F Rehfeld, G Liedberg, F Sundler

1 Citationer (Scopus)

Abstract

In the rat, gastric mucosal histamine is mobilized and histidine decarboxylase activated by treatment with insulin or pentagastrin. Colchicine pretreatment prevented the histamine release without preventing the enzyme activation. The results suggest a) that histamine release and histidine decarboxylase activation are independent events, and b) that microtubules are involved in the release of histamine.

Originalsprog	Engelsk
Tidsskrift	Experientia
Vol/bind	33
Udgave nummer	3
Sider (fra-til)	305-6
Antal sider	2
ISSN	0014-4754
DOI	https://doi.org/10.1007/BF02002794
Status	Udgivet - 15 mar. 1977
Udgivet eksternt	Ja

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10.1007/BF02002794

Citationsformater

@article{f4216f046d444d7ebf664af7fcc519ca,

title = "Colchicine inhibits stimulated release of gastric histamine but not activation of histidine decarboxylase",

abstract = "In the rat, gastric mucosal histamine is mobilized and histidine decarboxylase activated by treatment with insulin or pentagastrin. Colchicine pretreatment prevented the histamine release without preventing the enzyme activation. The results suggest a) that histamine release and histidine decarboxylase activation are independent events, and b) that microtubules are involved in the release of histamine.",

keywords = "Animals, Carboxy-Lyases/metabolism, Colchicine/pharmacology, Gastric Mucosa/drug effects, Histamine Release/drug effects, Histidine Decarboxylase/metabolism, Insulin/pharmacology, Male, Pentagastrin/pharmacology, Rats",

author = "R H{\aa}kanson and Rehfeld, {J F} and G Liedberg and F Sundler",

year = "1977",

month = mar,

day = "15",

doi = "10.1007/BF02002794",

language = "English",

volume = "33",

pages = "305--6",

journal = "Experientia",

issn = "0014-4754",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "3",

}

TY - JOUR

T1 - Colchicine inhibits stimulated release of gastric histamine but not activation of histidine decarboxylase

AU - Håkanson, R

AU - Rehfeld, J F

AU - Liedberg, G

AU - Sundler, F

PY - 1977/3/15

Y1 - 1977/3/15

N2 - In the rat, gastric mucosal histamine is mobilized and histidine decarboxylase activated by treatment with insulin or pentagastrin. Colchicine pretreatment prevented the histamine release without preventing the enzyme activation. The results suggest a) that histamine release and histidine decarboxylase activation are independent events, and b) that microtubules are involved in the release of histamine.

AB - In the rat, gastric mucosal histamine is mobilized and histidine decarboxylase activated by treatment with insulin or pentagastrin. Colchicine pretreatment prevented the histamine release without preventing the enzyme activation. The results suggest a) that histamine release and histidine decarboxylase activation are independent events, and b) that microtubules are involved in the release of histamine.

KW - Animals

KW - Carboxy-Lyases/metabolism

KW - Colchicine/pharmacology

KW - Gastric Mucosa/drug effects

KW - Histamine Release/drug effects

KW - Histidine Decarboxylase/metabolism

KW - Insulin/pharmacology

KW - Male

KW - Pentagastrin/pharmacology

KW - Rats

U2 - 10.1007/BF02002794

DO - 10.1007/BF02002794

M3 - Journal article

C2 - 67049

SN - 0014-4754

VL - 33

SP - 305

EP - 306

JO - Experientia

JF - Experientia

IS - 3

ER -

Colchicine inhibits stimulated release of gastric histamine but not activation of histidine decarboxylase

Abstract

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