TY - JOUR
T1 - Cohort profile
T2 - The PreEclampsia, Angiogenesis, Cardiac dysfunction and Hypertension (PEACH) Study
AU - Persson, Lisa Kristine Grange
AU - Lihme, Frederikke Fog
AU - Basit, Saima
AU - Larsen, Maria Oku
AU - Scheller, Nikolai Madrid
AU - Andersen, Anita Sylvest
AU - Halse, Karen Green
AU - Thorsen-Meyer, Annette
AU - Sørensen, Karina Meden
AU - Wohlfahrt, Jan
AU - Melbye, Mads
AU - Pihl, Kasper Kai Østrup
AU - Lykke, Jacob Alexander
AU - Boyd, Heather Allison
N1 - © 2022 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd.
PY - 2022/11
Y1 - 2022/11
N2 - BACKGROUND: Hypertensive disorders of pregnancy (HDP) remain a leading cause of maternal morbidity and mortality worldwide, with implications for maternal and neonatal well-being in the short term and for long-term maternal cardiovascular health. Although the mechanisms behind HDP remain incompletely understood, evidence suggests that preeclampsia in particular is a syndrome with more than one distinct subtype.OBJECTIVES: The PEACH (PreEclampsia, Angiogenesis, Cardiac dysfunction, Hypertension) Study was established to identify new HDP subtyping systems reflecting aetiology and prognosis and to find markers of later cardiovascular disease risk associated with preeclampsia.POPULATION: The PEACH Study recruited pregnant women referred to two Copenhagen-area hospitals with suspected preeclampsia (mean gestational age at enrolment: 36.7 weeks) and a group of frequency-matched pregnant women planning delivery at the same hospitals and healthy when enrolled mid-pregnancy.DESIGN: Prospective, longitudinal pregnancy cohort.METHODS: Participants underwent repeated third-trimester blood sample collection, longitudinal cardiac function assessments using the USCOM-1A during the third trimester and at 1 year postpartum and collection of placental samples immediately after delivery. Medical information was abstracted from medical records and hospital databases.PRELIMINARY RESULTS: During 2016-2018, we recruited 1149 pregnant women, of whom 1101 were followed to delivery. Among 691 women enrolled with suspected preeclampsia, 310 and 172 developed preeclampsia and gestational hypertension respectively. Among 410 women with healthy pregnancies when enrolled mid-pregnancy, 37 later developed hypertensive disorders of pregnancy. Of 1089 women still in the cohort 1 year postpartum, 578 (53.1%) participated in the follow-up assessment.CONCLUSIONS: The PEACH Study's rich data from women with and without HDP will enable us to identify new, clinically useful HDP subtypes to aid in decision-making regarding monitoring and treatment. Continued postpartum follow-up will help us develop algorithms to identify women at risk of persistent postpartum cardiac dysfunction and later cardiovascular disease after pregnancies complicated by HDP.
AB - BACKGROUND: Hypertensive disorders of pregnancy (HDP) remain a leading cause of maternal morbidity and mortality worldwide, with implications for maternal and neonatal well-being in the short term and for long-term maternal cardiovascular health. Although the mechanisms behind HDP remain incompletely understood, evidence suggests that preeclampsia in particular is a syndrome with more than one distinct subtype.OBJECTIVES: The PEACH (PreEclampsia, Angiogenesis, Cardiac dysfunction, Hypertension) Study was established to identify new HDP subtyping systems reflecting aetiology and prognosis and to find markers of later cardiovascular disease risk associated with preeclampsia.POPULATION: The PEACH Study recruited pregnant women referred to two Copenhagen-area hospitals with suspected preeclampsia (mean gestational age at enrolment: 36.7 weeks) and a group of frequency-matched pregnant women planning delivery at the same hospitals and healthy when enrolled mid-pregnancy.DESIGN: Prospective, longitudinal pregnancy cohort.METHODS: Participants underwent repeated third-trimester blood sample collection, longitudinal cardiac function assessments using the USCOM-1A during the third trimester and at 1 year postpartum and collection of placental samples immediately after delivery. Medical information was abstracted from medical records and hospital databases.PRELIMINARY RESULTS: During 2016-2018, we recruited 1149 pregnant women, of whom 1101 were followed to delivery. Among 691 women enrolled with suspected preeclampsia, 310 and 172 developed preeclampsia and gestational hypertension respectively. Among 410 women with healthy pregnancies when enrolled mid-pregnancy, 37 later developed hypertensive disorders of pregnancy. Of 1089 women still in the cohort 1 year postpartum, 578 (53.1%) participated in the follow-up assessment.CONCLUSIONS: The PEACH Study's rich data from women with and without HDP will enable us to identify new, clinically useful HDP subtypes to aid in decision-making regarding monitoring and treatment. Continued postpartum follow-up will help us develop algorithms to identify women at risk of persistent postpartum cardiac dysfunction and later cardiovascular disease after pregnancies complicated by HDP.
KW - Cardiovascular Diseases
KW - Female
KW - Heart Diseases
KW - Humans
KW - Hypertension, Pregnancy-Induced
KW - Infant, Newborn
KW - Placenta
KW - Pre-Eclampsia/epidemiology
KW - Pregnancy
KW - Prospective Studies
KW - cohort study
KW - longitudinal study
KW - preeclampsia
KW - gestational hypertension
KW - prospective study
KW - cardiovascular risk
UR - http://www.scopus.com/inward/record.url?scp=85135835660&partnerID=8YFLogxK
U2 - 10.1111/ppe.12917
DO - 10.1111/ppe.12917
M3 - Journal article
C2 - 35951739
SN - 1365-3016
VL - 36
SP - 863
EP - 878
JO - Paediatric and perinatal epidemiology
JF - Paediatric and perinatal epidemiology
IS - 6
ER -