Cohort profile: The COPENHAGEN Minipuberty Study-A longitudinal prospective cohort of healthy full-term infants and their parents

Alexander Siegfried Busch, Marie Lindhardt Ljubicic, Emmie N Upners, Margit Bistrup Fischer, Nanna Kolby, Camilla Eckert-Lind, Kirstine Jespersen, Anna-Maria Andersson, Hanne Frederiksen, Trine Holm Johannsen, Hanne Kristine Hegaard, Heidi Sharif, Casper P Hagen, Anders Juul

19 Citationer (Scopus)

Abstract

BACKGROUND: The hypothalamic-pituitary-gonadal (HPG) axis governs sexual maturation and reproductive function in humans. In early postnatal life, it is transiently active during which circulating sex steroids reach adult levels. While this so-called minipuberty represents a universal phenomenon in infants of both sexes, its role for early maturation and growth remains incompletely understood.

OBJECTIVES: To provide normative data on auxology as well as serum and urinary hormone levels in healthy, full-term infants throughout the first year of life and to investigate associations of postnatal HPG axis dynamics as well as hormonal, genetic and environmental exposures with early genital development and growth.

POPULATION: Healthy, Danish, full-term, singleton newborns including their parents.

DESIGN: Single-centre, prospective, observational longitudinal pregnancy and birth cohort.

METHODS: Newborns were followed with six repeated clinical examinations during a one-year follow-up period. An umbilical cord blood sample was drawn at birth. At each visit, infants underwent a clinical examination focusing on auxology and genital development. Further, blood (serum, plasma, DNA) and urine samples were collected at each visit. Mothers and fathers underwent a clinical examination and provided blood samples prior to and after birth. A subset of parents provided urine samples and breast milk samples. Pregnancy and obstetrical outcomes, and detailed parental questionnaires were compiled.

PRELIMINARY RESULTS: Between August 2016 and August 2018, 2481 women with singleton pregnancies were invited to participate of which 298, including their partners, were enrolled (12.0%). A total of 268 healthy, full-term newborns born appropriate for gestational age (AGA) were included at birth, 233 newborns participated in the postnatal follow-up period and 186 completed the one-year follow-up period (9.4% and 7.5%, respectively).

CONCLUSION: The COPENHAGEN Minipuberty Study provides detailed, longitudinal data on early genital development and growth including hormonal and genetic profiles and environmental exposure in healthy infants including additional data in their parents.

OriginalsprogEngelsk
TidsskriftPaediatric and Perinatal Epidemiology
Vol/bind35
Udgave nummer5
Sider (fra-til)601-611
Antal sider11
ISSN0269-5022
DOI
StatusUdgivet - sep. 2021

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