Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Clinical Utility of Measuring Inspiratory Neural Drive During Cardiopulmonary Exercise Testing (CPET)

Publikation: Bidrag til tidsskriftReviewpeer review

DOI

  1. Deep Learning for Diagnostic Binary Classification of Multiple-Lesion Skin Diseases

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Intradermal Tests With Drugs: An Approach to Standardization

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Echocardiographic abnormalities and predictors of mortality in hospitalized COVID-19 patients: the ECHOVID-19 study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. High prevalence of exercise-induced stridor during Parkrun: a cross-sectional field-based evaluation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. An evaluation of a throat discomfort visual analogue scale in chronic cough

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Assessing laryngeal function and hypersensitivity

    Publikation: Bidrag til tidsskriftReviewpeer review

Vis graf over relationer

Cardiopulmonary exercise testing (CPET) has traditionally included ventilatory and metabolic measurements alongside electrocardiographic characterization; however, research increasingly acknowledges the utility of also measuring inspiratory neural drive (IND) through its surrogate measure of diaphragmatic electromyography (EMGdi). While true IND also encompasses the activation of non-diaphragmatic respiratory muscles, the current review focuses on diaphragmatic measurements, providing information about additional inspiratory muscle groups for context where appropriate. Evaluation of IND provides mechanistic insight into the origins of dyspnea and exercise limitation across pathologies; yields valuable information reflecting the integration of diverse mechanical, chemical, locomotor, and metabolic afferent signals; and can help assess the efficacy of therapeutic interventions. Further, IND measurement during the physiologic stress of exercise is uniquely poised to reveal the underpinnings of physiologic limitations masked during resting and unloaded breathing, with important information provided not only at peak exercise, but throughout exercise protocols. As our understanding of IND presentation across varying conditions continues to grow and methods for its measurement become more accessible, the translation of these principles into clinical settings is a logical next step in facilitating appropriate and nuanced management tailored to each individual's unique physiology. This review provides an overview of the current state of understanding of IND measurement during CPET: its origins, known patterns of behavior and links with dyspnea in health and major respiratory diseases, and the possibility of expanding this approach to applications beyond exercise.

OriginalsprogEngelsk
Artikelnummer2020.00483
TidsskriftFrontiers in Medicine
Vol/bind7
Sider (fra-til)483
ISSN2296-858X
DOI
StatusUdgivet - 2020

Bibliografisk note

Copyright © 2020 Domnik, Walsted and Langer.

ID: 61116354