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Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status

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@article{6d2d33cad40442aa9882d039a8c920ec,
title = "Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status",
abstract = "Axillary lymph node status is an important prognostic factor for breast cancer patients and sentinel lymph node biopsy (SLNB) is a less invasive surgical proxy. We examined if consecutively derived molecular subtypes from primary breast cancers provide additional predictive value for SLNB status. 1556 patients with a breast cancer > 10 mm underwent primary surgical procedure including SLNB and tumor specimens were assigned with a transcriptomics-based molecular subtype. 1020 patients had a negative sentinel node (SN) and 536 a positive. A significant association between tumor size and SN status (p < 0.0001) was found across all samples, but no association between size and SN status (p = 0.14) was found for BasL tumors. A BasL subtype was a predictor of an SN-negative status (p = 0.001, OR 0.58, 95% CI 0.38;0.90) and among the BasL, postmenopausal status was a predictor for SN-negative status (p = 0.01). Overall survival was significantly lower (p = 0.02) in patients with BasL tumors and a positive SN. Interestingly, we identified a significant correlation between hormone receptor activity and SN status within the BasL subtype. Taken together, molecular subtypes and hormone receptor activity of breast cancers add predictive value for SLNB status.",
keywords = "BRCA1 Protein/metabolism, BRCA2 Protein/metabolism, Breast Neoplasms/classification, Cohort Studies, Female, Humans, Logistic Models, Menopause, Principal Component Analysis, Receptors, Estrogen/metabolism, Sentinel Lymph Node/pathology, Survival Analysis, Tumor Burden",
author = "Maria Rossing and Pedersen, {Christina Bligaard} and Tove Tvedskov and Ilse Vejborg and Talman, {Maj Lis} and Olsen, {Lars R{\o}nn} and Niels Kroman and Nielsen, {Finn Cilius} and Jensen, {Maj Britt} and Bent Ejlertsen",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jan,
day = "26",
doi = "10.1038/s41598-021-81538-4",
language = "English",
volume = "11",
pages = "2259",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status

AU - Rossing, Maria

AU - Pedersen, Christina Bligaard

AU - Tvedskov, Tove

AU - Vejborg, Ilse

AU - Talman, Maj Lis

AU - Olsen, Lars Rønn

AU - Kroman, Niels

AU - Nielsen, Finn Cilius

AU - Jensen, Maj Britt

AU - Ejlertsen, Bent

N1 - Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1/26

Y1 - 2021/1/26

N2 - Axillary lymph node status is an important prognostic factor for breast cancer patients and sentinel lymph node biopsy (SLNB) is a less invasive surgical proxy. We examined if consecutively derived molecular subtypes from primary breast cancers provide additional predictive value for SLNB status. 1556 patients with a breast cancer > 10 mm underwent primary surgical procedure including SLNB and tumor specimens were assigned with a transcriptomics-based molecular subtype. 1020 patients had a negative sentinel node (SN) and 536 a positive. A significant association between tumor size and SN status (p < 0.0001) was found across all samples, but no association between size and SN status (p = 0.14) was found for BasL tumors. A BasL subtype was a predictor of an SN-negative status (p = 0.001, OR 0.58, 95% CI 0.38;0.90) and among the BasL, postmenopausal status was a predictor for SN-negative status (p = 0.01). Overall survival was significantly lower (p = 0.02) in patients with BasL tumors and a positive SN. Interestingly, we identified a significant correlation between hormone receptor activity and SN status within the BasL subtype. Taken together, molecular subtypes and hormone receptor activity of breast cancers add predictive value for SLNB status.

AB - Axillary lymph node status is an important prognostic factor for breast cancer patients and sentinel lymph node biopsy (SLNB) is a less invasive surgical proxy. We examined if consecutively derived molecular subtypes from primary breast cancers provide additional predictive value for SLNB status. 1556 patients with a breast cancer > 10 mm underwent primary surgical procedure including SLNB and tumor specimens were assigned with a transcriptomics-based molecular subtype. 1020 patients had a negative sentinel node (SN) and 536 a positive. A significant association between tumor size and SN status (p < 0.0001) was found across all samples, but no association between size and SN status (p = 0.14) was found for BasL tumors. A BasL subtype was a predictor of an SN-negative status (p = 0.001, OR 0.58, 95% CI 0.38;0.90) and among the BasL, postmenopausal status was a predictor for SN-negative status (p = 0.01). Overall survival was significantly lower (p = 0.02) in patients with BasL tumors and a positive SN. Interestingly, we identified a significant correlation between hormone receptor activity and SN status within the BasL subtype. Taken together, molecular subtypes and hormone receptor activity of breast cancers add predictive value for SLNB status.

KW - BRCA1 Protein/metabolism

KW - BRCA2 Protein/metabolism

KW - Breast Neoplasms/classification

KW - Cohort Studies

KW - Female

KW - Humans

KW - Logistic Models

KW - Menopause

KW - Principal Component Analysis

KW - Receptors, Estrogen/metabolism

KW - Sentinel Lymph Node/pathology

KW - Survival Analysis

KW - Tumor Burden

UR - http://www.scopus.com/inward/record.url?scp=85099863583&partnerID=8YFLogxK

U2 - 10.1038/s41598-021-81538-4

DO - 10.1038/s41598-021-81538-4

M3 - Journal article

C2 - 33500440

AN - SCOPUS:85099863583

VL - 11

SP - 2259

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 2259

ER -

ID: 66207053