Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Clinical features and disease course of primary angioedema patients in a tertiary care hospital

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Fertility Treatment Resulting in Live Births in Women with Asthma - Associated with Perennial Allergy?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Female asthma and atopy - impact on fertility: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Postpartum airway responsiveness and exacerbation of asthma during pregnancy - a pilot study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Incidence and risk factors for exacerbations of asthma during pregnancy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Safety of bronchodilators and corticosteroids for asthma during pregnancy: what we know and what we need to do better

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Development of depression in patients with oral cavity cancer: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Chronic rhinosinusitis in COPD: A prevalent but unrecognized comorbidity impacting health related quality of life

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Face masks for the prevention of COVID-19 - Rationale and design of the randomised controlled trial DANMASK-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Association between head and neck cancer and sexually transmitted diseases: a Danish nationwide, case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Circulating tumour DNA alterations as biomarkers for head and neck cancer: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Purpose: To give a better understanding of primary AE, the clinical characteristics and the possible therapeutic approaches. Background: Angioedema (AE) is a non-pitting, non-itching swelling of skin or mucosa. The symptom can become life-threatening if located in the airways. Primary (monosympto-matic) AE is a manifestation of several different diseases and the diagnosis is not always straight-forward. The aetiological and pathophysiological factors of primary AE are not completely clarified. There is a need for further investigation. Patients and Methods: This was a retrospective cohort study of patients referred to an outpatient dermatology clinic in a tertiary care hospital for clinical assessment due to primary AE in the period from 1996 to 2014. Results: A total of 315 patients were identified with primary AE. The most frequent subtype was idiopathic AE (42.5%) and the second most common was angiotensin-converting enzymeinhibitor (ACEi)-induced AE (31.1%). Three patients were diagnosed with hereditary AE and one patient was diagnosed with acquired C1-inhibitor deficiency. At least 107 (34.0%) patients had established histaminergic AE. More than 1/3 of the patients were treated in an emergency room or hospitalized due to AE. A 98.1% of patients had experienced AE in the head and neck area. Seven patients were in the need of acute airway intervention. Six of these had ACEi-induced AE. Female sex and smoking were found to be risk factors for developing AE. Conclusion: The most frequent diagnoses were histaminergic-, non-histaminergic idiopathic AE and ACEi-induced AE, whereas complement C1-inhibitor deficiency was rare. Histaminergic AE made up a substantial group of patients with primary AE. Even though there are different pathophysiological causes of AE, many cases have overlapping clinical manifestations, which make diagnosis and treatment difficult.

OriginalsprogEngelsk
TidsskriftJournal of Asthma and Allergy
Vol/bind13
Sider (fra-til)225-236
Antal sider12
ISSN1178-6965
DOI
StatusUdgivet - 1 jan. 2020

ID: 60544819