TY - JOUR
T1 - Clinical endocrinology and metabolism. Cholecystokinin
AU - Rehfeld, Jens F
PY - 2004/12
Y1 - 2004/12
N2 - Cholecystokinin (CCK) is a peptide hormone discovered in the small intestine. Together with secretin and gastrin, CCK constitutes the classical gut hormone triad. In addition to gallbladder contraction, CCK also regulates pancreatic enzyme secretion and growth, intestinal motility, satiety signalling and the inhibition of gastric acid secretion. CCK is, however, also a transmitter in central and intestinal neurons. Notably, CCK is the most abundant neuropeptide in the human brain. Owing to difficulties in developing accurate assays, knowledge about CCK secretion in disease is limited. Available data indicate, however, that proCCK is expressed in certain neuroendocrine tumours and sarcomas, whereas the secretion of CCK is impaired in celiac disease and bulimia nervosa. Stimulation with exogenous CCK has proved useful in diagnostic tests of gallbladder and pancreatic diseases, as well as medullary thyroid carcinomas.
AB - Cholecystokinin (CCK) is a peptide hormone discovered in the small intestine. Together with secretin and gastrin, CCK constitutes the classical gut hormone triad. In addition to gallbladder contraction, CCK also regulates pancreatic enzyme secretion and growth, intestinal motility, satiety signalling and the inhibition of gastric acid secretion. CCK is, however, also a transmitter in central and intestinal neurons. Notably, CCK is the most abundant neuropeptide in the human brain. Owing to difficulties in developing accurate assays, knowledge about CCK secretion in disease is limited. Available data indicate, however, that proCCK is expressed in certain neuroendocrine tumours and sarcomas, whereas the secretion of CCK is impaired in celiac disease and bulimia nervosa. Stimulation with exogenous CCK has proved useful in diagnostic tests of gallbladder and pancreatic diseases, as well as medullary thyroid carcinomas.
KW - Animals
KW - Cholecystokinin/biosynthesis
KW - Gastrointestinal Hormones/physiology
KW - Humans
KW - Receptors, Cholecystokinin/physiology
U2 - 10.1016/j.beem.2004.07.002
DO - 10.1016/j.beem.2004.07.002
M3 - Review
C2 - 15533776
SN - 1521-690X
VL - 18
SP - 569
EP - 586
JO - Best practice & research. Clinical endocrinology & metabolism
JF - Best practice & research. Clinical endocrinology & metabolism
IS - 4
ER -