Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Clinical characteristics and a rising incidence of early-onset colorectal cancer in a nationwide cohort of 521 patients aged 18-40 years

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Parental occupational organic dust exposure and selected childhood cancers in Denmark 1968-2016

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Rational targeting of population groups and residential areas for colorectal cancer screening

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Answer to: "Is the National Danish Colorectal Cancer Screening Programme a success?"

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  4. Birthweight and risk of thyroid cancer and its histological types: A large cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The incidence of early-onset colorectal cancer (eoCRC) has been reported to increase, and patients with eoCRC seem to be diagnosed at more advanced stages compared to elderly patients. The aim of this study was to describe patient and disease characteristics, symptomatology and the incidence of eoCRC in a national cohort.

MATERIALS AND METHODS: 521 eoCRC patients (≤40 years old) diagnosed with histologically verified colorectal cancer (CRC) during the years 2001-2013 were identified in national databases and compared to more than 15,000 CRC patients aged 66-75 years. Age-adjusted incidence was calculated for eoCRC patients and various sub-analyses were performed.

RESULTS: More advanced stages were seen in eoCRC patients compared to elderly patients (stage II: p < 0.001, III: p = 0.01 and IV: p < 0.01). Differences were statistically significant in colon cancer, but not in rectal cancer. A significant difference in sex distribution was seen between right and left-sided tumors in the eoCRC group. The age-adjusted incidence rate increased during the study period (1.60-2.55 per 100.000), and significant annual percent changes (APC) were seen in young females (APC = 4.73) and left-sided tumor localization (including rectal cancer) (APC = 4.54), respectively.

CONCLUSION: In this nationwide cohort of eoCRC patients, our results confirm that young patients are diagnosed at advanced stages, and that the incidence of eoCRC is increasing.

OriginalsprogEngelsk
Artikelnummer101704
TidsskriftCancer epidemiology
Vol/bind66
ISSN1877-7821
DOI
StatusUdgivet - 1 jun. 2020

Bibliografisk note

Copyright © 2020 Elsevier Ltd. All rights reserved.

ID: 59656434