Classification of hepatitis B virus genotype B into 2 major types based on characterization of a novel subgenotype in Arctic indigenous populations

Tomoyuki Sakamoto; Yasuhito Tanaka; Josephine Simonetti; Carla Osiowy; Malene L Borresen; Anders Koch; Fuat Kurbanov; Masaya Sugiyama; Gerald Y Minuk; Brian J McMahon; Takashi Joh; Masashi Mizokami

doi:10.1086/523111

Classification of hepatitis B virus genotype B into 2 major types based on characterization of a novel subgenotype in Arctic indigenous populations

Tomoyuki Sakamoto, Yasuhito Tanaka, Josephine Simonetti, Carla Osiowy, Malene L Borresen, Anders Koch, Fuat Kurbanov, Masaya Sugiyama, Gerald Y Minuk, Brian J McMahon, Takashi Joh, Masashi Mizokami

68 Citationer (Scopus)

Abstract

Hepatitis B virus genotype B (HBV/B) has been classified into 5 subgenotypes. Except for Bj/B1 in Japan, the subgenotypes (Ba/B2-B5) have undergone recombination with HBV/C in the core promoter/precore/core genomic region. Phylogenetic analyses of complete sequences show that the Arctic strains belong to a novel subgenotype (HBV/B6) without the recombination, analogous to what is seen with Bj/B1. Comparison of 50 HBV/B6 carriers from the Arctic versus 50 Bj and 50 Ba age- and sex-matched carriers from Asia revealed that clinical characteristics of HBV/B6 carriers were similar to those of Bj/B1 carriers in Japan. The results suggest that HBV/B may be classified into nonrecombinant (Bj/B1 and B6) and recombinant (Ba/B2-B5) types.

Originalsprog	Engelsk
Tidsskrift	The Journal of infectious diseases
Vol/bind	196
Udgave nummer	10
Sider (fra-til)	1487-92
Antal sider	6
ISSN	0022-1899
DOI	https://doi.org/10.1086/523111
Status	Udgivet - 15 nov. 2007
Udgivet eksternt	Ja

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10.1086/523111

Citationsformater

Sakamoto, T., Tanaka, Y., Simonetti, J., Osiowy, C., Borresen, M. L., Koch, A., Kurbanov, F., Sugiyama, M., Minuk, G. Y., McMahon, B. J., Joh, T., & Mizokami, M. (2007). Classification of hepatitis B virus genotype B into 2 major types based on characterization of a novel subgenotype in Arctic indigenous populations. The Journal of infectious diseases, 196(10), 1487-92. https://doi.org/10.1086/523111

Classification of hepatitis B virus genotype B into 2 major types based on characterization of a novel subgenotype in Arctic indigenous populations. / Sakamoto, Tomoyuki; Tanaka, Yasuhito; Simonetti, Josephine et al.
I: The Journal of infectious diseases, Bind 196, Nr. 10, 15.11.2007, s. 1487-92.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Sakamoto, T, Tanaka, Y, Simonetti, J, Osiowy, C, Borresen, ML, Koch, A, Kurbanov, F, Sugiyama, M, Minuk, GY, McMahon, BJ, Joh, T & Mizokami, M 2007, 'Classification of hepatitis B virus genotype B into 2 major types based on characterization of a novel subgenotype in Arctic indigenous populations', The Journal of infectious diseases, bind 196, nr. 10, s. 1487-92. https://doi.org/10.1086/523111

@article{c686ee72f7254009b52913e936c3faf0,

title = "Classification of hepatitis B virus genotype B into 2 major types based on characterization of a novel subgenotype in Arctic indigenous populations",

abstract = "Hepatitis B virus genotype B (HBV/B) has been classified into 5 subgenotypes. Except for Bj/B1 in Japan, the subgenotypes (Ba/B2-B5) have undergone recombination with HBV/C in the core promoter/precore/core genomic region. Phylogenetic analyses of complete sequences show that the Arctic strains belong to a novel subgenotype (HBV/B6) without the recombination, analogous to what is seen with Bj/B1. Comparison of 50 HBV/B6 carriers from the Arctic versus 50 Bj and 50 Ba age- and sex-matched carriers from Asia revealed that clinical characteristics of HBV/B6 carriers were similar to those of Bj/B1 carriers in Japan. The results suggest that HBV/B may be classified into nonrecombinant (Bj/B1 and B6) and recombinant (Ba/B2-B5) types.",

keywords = "Arctic Regions/epidemiology, Case-Control Studies, Female, Genome, Viral, Genotype, Hepatitis B/epidemiology, Hepatitis B virus/classification, Humans, Male, Middle Aged, Population Groups",

author = "Tomoyuki Sakamoto and Yasuhito Tanaka and Josephine Simonetti and Carla Osiowy and Borresen, {Malene L} and Anders Koch and Fuat Kurbanov and Masaya Sugiyama and Minuk, {Gerald Y} and McMahon, {Brian J} and Takashi Joh and Masashi Mizokami",

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doi = "10.1086/523111",

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AU - Sakamoto, Tomoyuki

AU - Tanaka, Yasuhito

AU - Simonetti, Josephine

AU - Osiowy, Carla

AU - Borresen, Malene L

AU - Koch, Anders

AU - Kurbanov, Fuat

AU - Sugiyama, Masaya

AU - Minuk, Gerald Y

AU - McMahon, Brian J

AU - Joh, Takashi

AU - Mizokami, Masashi

PY - 2007/11/15

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N2 - Hepatitis B virus genotype B (HBV/B) has been classified into 5 subgenotypes. Except for Bj/B1 in Japan, the subgenotypes (Ba/B2-B5) have undergone recombination with HBV/C in the core promoter/precore/core genomic region. Phylogenetic analyses of complete sequences show that the Arctic strains belong to a novel subgenotype (HBV/B6) without the recombination, analogous to what is seen with Bj/B1. Comparison of 50 HBV/B6 carriers from the Arctic versus 50 Bj and 50 Ba age- and sex-matched carriers from Asia revealed that clinical characteristics of HBV/B6 carriers were similar to those of Bj/B1 carriers in Japan. The results suggest that HBV/B may be classified into nonrecombinant (Bj/B1 and B6) and recombinant (Ba/B2-B5) types.

AB - Hepatitis B virus genotype B (HBV/B) has been classified into 5 subgenotypes. Except for Bj/B1 in Japan, the subgenotypes (Ba/B2-B5) have undergone recombination with HBV/C in the core promoter/precore/core genomic region. Phylogenetic analyses of complete sequences show that the Arctic strains belong to a novel subgenotype (HBV/B6) without the recombination, analogous to what is seen with Bj/B1. Comparison of 50 HBV/B6 carriers from the Arctic versus 50 Bj and 50 Ba age- and sex-matched carriers from Asia revealed that clinical characteristics of HBV/B6 carriers were similar to those of Bj/B1 carriers in Japan. The results suggest that HBV/B may be classified into nonrecombinant (Bj/B1 and B6) and recombinant (Ba/B2-B5) types.

KW - Arctic Regions/epidemiology

KW - Case-Control Studies

KW - Female

KW - Genome, Viral

KW - Genotype

KW - Hepatitis B/epidemiology

KW - Hepatitis B virus/classification

KW - Humans

KW - Male

KW - Middle Aged

KW - Population Groups

U2 - 10.1086/523111

DO - 10.1086/523111

M3 - Journal article

C2 - 18008228

SN - 0022-1899

VL - 196

SP - 1487

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JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

IS - 10

ER -

Classification of hepatitis B virus genotype B into 2 major types based on characterization of a novel subgenotype in Arctic indigenous populations

Abstract

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