Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Classics in Neuroimaging: The Serotonergic 2A Receptor System-from Discovery to Modern Molecular Imaging

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Development and Evaluation of Two Potential 5-HT7 Receptor PET Tracers: [18F]ENL09 and [18F]ENL10

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Development and Evaluation of Two Potential 5-HT7Receptor PET Tracers: [18F]ENL09 and [18F]ENL10

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Structural brain abnormalities associated with cognitive impairments in bipolar disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. NeuroPharm study: EEG wakefulness regulation as a biomarker in MDD

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Already in 1953, Woolley and Shaw speculated that serotonin could be involved in a range of central nervous system (CNS) disorders. Lysergic acid diethylamide (LSD) displayed an important role in this respect. It was used not only to antagonize biological effects of serotonin and to study the system itself, but also to identify serotonergic subtype receptors. The 5-HT2A receptor was discovered in the 1970s and identified as the responsible receptor mediating psychedelic effects of LSD. The development of positron emission tomography (PET) allowed to study this receptor system in vivo. Parameters such as abundance of 5-HT2A neuroreceptors or receptor occupancy can be determined using PET. As such, the development of 5-HT2A receptor tracers started immediately after the introduction of PET in the mid-1970s. In this Viewpoint, we provide a historical overview from the discovery of serotonin to the identification of the 5-HT2A receptor subtype and the subsequent development of 5-HT2A receptor subtype specific PET tracers over the last four decades. We emphasize the interplay between pharmacology, medicinal chemistry, radiochemistry, and nuclear medicine that is important while developing a PET tracer. Moreover, we highlight selected examples applying 5-HT2A receptor PET tracers within neurological diseases and drug occupancy studies.

OriginalsprogEngelsk
TidsskriftACS Chemical Neuroscience
Vol/bind9
Udgave nummer6
Sider (fra-til)1226-1229
Antal sider4
ISSN1948-7193
DOI
StatusUdgivet - 20 jun. 2018

ID: 56309458