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Citrate NMR peak irreproducibility in blood samples after reacquisition of spectra

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BACKGROUND: In our metabolomics studies we have noticed that repeated NMR acquisition on the same sample can result in altered metabolite signal intensities.

AIMS: To investigate the reproducibility of repeated NMR acquisition on selected metabolites in serum and plasma from two large human metabolomics studies.

METHODS: Two peak regions for each metabolite were integrated and changes occurring after reacquisition were correlated.

RESULTS: Integral changes were generally small, but serum citrate signals decreased significantly in some samples.

CONCLUSIONS: Several metabolite integrals were not reproducible in some of the repeated spectra. Following established protocols, randomising analysis order and biomarker validation are important.

OriginalsprogEngelsk
TidsskriftMetabolomics
Vol/bind16
Udgave nummer1
Sider (fra-til)7
ISSN1573-3882
DOI
StatusUdgivet - 2019

ID: 58987242