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Region Hovedstaden - en del af Københavns Universitetshospital
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Circulating YKL-40 in patients with essential thrombocythemia and polycythemia vera treated with the novel histone deacetylase inhibitor vorinostat

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Christen Lykkegaard Andersen
  • Mads Emil Bjørn
  • Mary Frances McMullin
  • Claire Harrison
  • Jan Samuelsson
  • Elisabeth Ejerblad
  • Sonja Zweegman
  • Savio Fernandes
  • David Bareford
  • Steven Knapper
  • Eva Löfvenberg
  • Olle Linder
  • Bjørn Andreasson
  • Erik Ahlstrand
  • Morten Krogh Jensen
  • Ole Weis Bjerrum
  • Hanne Vestergaard
  • Herdis Larsen
  • Tobias Wirenfeldt Klausen
  • Torben Mourits-Andersen
  • Vibe Skov
  • Mads Thomassen
  • Torben Kruse
  • Kirsten Grønbæk
  • Hans Carl Hasselbalch
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YKL-40 regulates vascular endothelial growth factors and induces tumor proliferation. We investigated YKL-40 before and after treatment with vorinostat in 31 polycythemia vera (PV) and 16 essential thrombocythemia (ET) patients. Baseline PV patient levels were 2 times higher than in healthy controls (P<0.0001) and 1.7 times higher than in ET (P=0.02). A significant correlation between YKL-40 at baseline and neutrophils, CRP, LDH, JAK2V617F and platelets in PV patients was observed, as well as a significantly greater reduction of YKL-40 levels in PV patients responding to therapy. YKL-40 might be a novel marker of disease burden and progression in myeloproliferative neoplasms.

OriginalsprogEngelsk
TidsskriftLeukemia Research
Vol/bind38
Udgave nummer7
Sider (fra-til)816-21
Antal sider6
ISSN0145-2126
DOI
StatusUdgivet - jul. 2014

ID: 44378499