TY - JOUR
T1 - Circulating tumour DNA in the treatment of cancer
AU - Johansen, Amanda Frydendahl Boll
AU - Øgaard, Nadia
AU - Kongsfelt, Iben Boutrup
AU - Egebjerg, Kristian
AU - Andersen, Claus Lindbjerg
AU - Mau-Sørensen, Morten
AU - Iden, Cecilie Riis
PY - 2021/8/9
Y1 - 2021/8/9
N2 - Circulating tumour DNA analysis has a potential to improve multiple aspects of cancer management. This includes: a) early cancer detection in asymptomatic individuals, b) identification of patients with residual disease after curative intended treatment, c) patient stratification in relation to treatment decisions like adjuvant therapy and intensity of radiological surveillance, d) monitoring treatment effect for optimised adaptive therapy, e) identification of actionable targets, and f) early recurrence detection. These points are summarised in this review.
AB - Circulating tumour DNA analysis has a potential to improve multiple aspects of cancer management. This includes: a) early cancer detection in asymptomatic individuals, b) identification of patients with residual disease after curative intended treatment, c) patient stratification in relation to treatment decisions like adjuvant therapy and intensity of radiological surveillance, d) monitoring treatment effect for optimised adaptive therapy, e) identification of actionable targets, and f) early recurrence detection. These points are summarised in this review.
KW - Circulating Tumor DNA/genetics
KW - Early Detection of Cancer
KW - Humans
KW - Neoplasms/diagnosis
UR - http://www.scopus.com/inward/record.url?scp=85113892383&partnerID=8YFLogxK
M3 - Review
C2 - 34378526
SN - 0041-5782
VL - 183
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
IS - 32
ER -