Circulating tumour DNA in the treatment of cancer

Amanda Frydendahl Boll Johansen, Nadia Øgaard, Iben Boutrup Kongsfelt, Kristian Egebjerg, Claus Lindbjerg Andersen, Morten Mau-Sørensen, Cecilie Riis Iden

Abstract

Circulating tumour DNA analysis has a potential to improve multiple aspects of cancer management. This includes: a) early cancer detection in asymptomatic individuals, b) identification of patients with residual disease after curative intended treatment, c) patient stratification in relation to treatment decisions like adjuvant therapy and intensity of radiological surveillance, d) monitoring treatment effect for optimised adaptive therapy, e) identification of actionable targets, and f) early recurrence detection. These points are summarised in this review.

OriginalsprogEngelsk
TidsskriftUgeskrift for Laeger
Vol/bind183
Udgave nummer32
ISSN0041-5782
StatusUdgivet - 9 aug. 2021

Emneord

  • Circulating Tumor DNA/genetics
  • Early Detection of Cancer
  • Humans
  • Neoplasms/diagnosis

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