Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis

Anne Friesgaard Christensen; Grith Lykke Sørensen; Kim Hørslev-Petersen; Uffe Holmskov; Hanne Merete Lindegaard; Kirsten Junker; Merete Lund Hetland; Kristian Stengaard-Pedersen; Søren Jacobsen; Tine Lottenburger; Torkell Ellingsen; Lis Smedegaard Andersen; Ib Hansen; Henrik Skjødt; Jens Kristian Pedersen; Ulrik Birk Lauridsen; Anders Svendsen; Ulrik Tarp; Jan Pødenphant; Aage Vestergaard; Anne Grethe Jurik; Mikkel Østergaard; Peter Junker

doi:10.1186/ar2948

Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis

Anne Friesgaard Christensen, Grith Lykke Sørensen, Kim Hørslev-Petersen, Uffe Holmskov, Hanne Merete Lindegaard, Kirsten Junker, Merete Lund Hetland, Kristian Stengaard-Pedersen, Søren Jacobsen, Tine Lottenburger, Torkell Ellingsen, Lis Smedegaard Andersen, Ib Hansen, Henrik Skjødt, Jens Kristian Pedersen, Ulrik Birk Lauridsen, Anders Svendsen, Ulrik Tarp, Jan Pødenphant, Aage VestergaardAnne Grethe Jurik, Mikkel Østergaard, Peter Junker

Funktions- og Billeddiagnostisk Enhed, Røntgensektion

19 Citationer (Scopus)

Abstract

Surfactant protein D (SP-D) is a collectin with immuno-regulatory functions, which may depend on oligomerization. Anti-microbial and anti-inflammatory properties have been attributed to multimeric SP-D variants, while trimeric subunits per se have been suggested to enhance inflammation. Previously, we reported low circulating SP-D in early rheumatoid arthritis (RA), and the present investigation aims to extend these data by serial SP-D serum measurements, studies on synovial fluid, SP-D size distribution and genotyping in patients with early RA.

Originalsprog	Engelsk
Tidsskrift	Arthritis Research & Therapy
Vol/bind	12
Udgave nummer	2
Sider (fra-til)	R39
ISSN	1478-6354
DOI	https://doi.org/10.1186/ar2948
Status	Udgivet - 1 jan. 2010

Adgang til dokumentet

10.1186/ar2948

Citationsformater

Christensen, A. F., Sørensen, G. L., Hørslev-Petersen, K., Holmskov, U., Lindegaard, H. M., Junker, K., Hetland, M. L., Stengaard-Pedersen, K., Jacobsen, S., Lottenburger, T., Ellingsen, T., Andersen, L. S., Hansen, I., Skjødt, H., Pedersen, J. K., Lauridsen, U. B., Svendsen, A., Tarp, U., Pødenphant, J., ... Junker, P. (2010). Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis. Arthritis Research & Therapy, 12(2), R39. https://doi.org/10.1186/ar2948

Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis. / Christensen, Anne Friesgaard; Sørensen, Grith Lykke; Hørslev-Petersen, Kim et al.
I: Arthritis Research & Therapy, Bind 12, Nr. 2, 01.01.2010, s. R39.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Christensen, AF, Sørensen, GL, Hørslev-Petersen, K, Holmskov, U, Lindegaard, HM, Junker, K, Hetland, ML, Stengaard-Pedersen, K, Jacobsen, S, Lottenburger, T, Ellingsen, T, Andersen, LS, Hansen, I, Skjødt, H, Pedersen, JK, Lauridsen, UB, Svendsen, A, Tarp, U, Pødenphant, J, Vestergaard, A, Jurik, AG, Østergaard, M & Junker, P 2010, 'Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis', Arthritis Research & Therapy, bind 12, nr. 2, s. R39. https://doi.org/10.1186/ar2948

@article{78af6074a27840238260860b7b9eaa86,

title = "Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis",

abstract = "Surfactant protein D (SP-D) is a collectin with immuno-regulatory functions, which may depend on oligomerization. Anti-microbial and anti-inflammatory properties have been attributed to multimeric SP-D variants, while trimeric subunits per se have been suggested to enhance inflammation. Previously, we reported low circulating SP-D in early rheumatoid arthritis (RA), and the present investigation aims to extend these data by serial SP-D serum measurements, studies on synovial fluid, SP-D size distribution and genotyping in patients with early RA.",

author = "Christensen, {Anne Friesgaard} and S{\o}rensen, {Grith Lykke} and Kim H{\o}rslev-Petersen and Uffe Holmskov and Lindegaard, {Hanne Merete} and Kirsten Junker and Hetland, {Merete Lund} and Kristian Stengaard-Pedersen and S{\o}ren Jacobsen and Tine Lottenburger and Torkell Ellingsen and Andersen, {Lis Smedegaard} and Ib Hansen and Henrik Skj{\o}dt and Pedersen, {Jens Kristian} and Lauridsen, {Ulrik Birk} and Anders Svendsen and Ulrik Tarp and Jan P{\o}denphant and Aage Vestergaard and Jurik, {Anne Grethe} and Mikkel {\O}stergaard and Peter Junker",

year = "2010",

month = jan,

day = "1",

doi = "10.1186/ar2948",

language = "English",

volume = "12",

pages = "R39",

journal = "Arthritis Research & Therapy",

issn = "1478-6354",

publisher = "BioMed Central Ltd",

number = "2",

}

TY - JOUR

T1 - Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis

AU - Christensen, Anne Friesgaard

AU - Sørensen, Grith Lykke

AU - Hørslev-Petersen, Kim

AU - Holmskov, Uffe

AU - Lindegaard, Hanne Merete

AU - Junker, Kirsten

AU - Hetland, Merete Lund

AU - Stengaard-Pedersen, Kristian

AU - Jacobsen, Søren

AU - Lottenburger, Tine

AU - Ellingsen, Torkell

AU - Andersen, Lis Smedegaard

AU - Hansen, Ib

AU - Skjødt, Henrik

AU - Pedersen, Jens Kristian

AU - Lauridsen, Ulrik Birk

AU - Svendsen, Anders

AU - Tarp, Ulrik

AU - Pødenphant, Jan

AU - Vestergaard, Aage

AU - Jurik, Anne Grethe

AU - Østergaard, Mikkel

AU - Junker, Peter

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Surfactant protein D (SP-D) is a collectin with immuno-regulatory functions, which may depend on oligomerization. Anti-microbial and anti-inflammatory properties have been attributed to multimeric SP-D variants, while trimeric subunits per se have been suggested to enhance inflammation. Previously, we reported low circulating SP-D in early rheumatoid arthritis (RA), and the present investigation aims to extend these data by serial SP-D serum measurements, studies on synovial fluid, SP-D size distribution and genotyping in patients with early RA.

AB - Surfactant protein D (SP-D) is a collectin with immuno-regulatory functions, which may depend on oligomerization. Anti-microbial and anti-inflammatory properties have been attributed to multimeric SP-D variants, while trimeric subunits per se have been suggested to enhance inflammation. Previously, we reported low circulating SP-D in early rheumatoid arthritis (RA), and the present investigation aims to extend these data by serial SP-D serum measurements, studies on synovial fluid, SP-D size distribution and genotyping in patients with early RA.

U2 - 10.1186/ar2948

DO - 10.1186/ar2948

M3 - Journal article

C2 - 20211020

SN - 1478-6354

VL - 12

SP - R39

JO - Arthritis Research & Therapy

JF - Arthritis Research & Therapy

IS - 2

ER -

Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater