Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Circulating nociceptin and CGRP in medication-overuse headache

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Neurostimulation for the treatment of chronic migraine and cluster headache

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Personality traits in migraine and medication-overuse headache: A comparative study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Treatment of spatial neglect in clinical practice: A nationwide survey

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Optical coherence tomography in acute optic neuritis: A population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Married, unmarried, divorced, and widowed and the risk of stroke

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Episodic and Chronic Cluster Headache: Differences in Family History, Traumatic Head Injury, and Chronorisk

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Monitoring chronic headache and medication-overuse headache prevalence in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Diagnostic delay of cluster headache: A cohort study from the Danish Cluster Headache Survey

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Medication-overuse headache: The effect of a patient educational programme-A randomized controlled trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. More precise phenotyping of cluster headache using prospective attack reports

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Previous studies found low serum levels of nociceptin in migraine patients but high serum levels of calcitonin gene-related peptide (CGRP). CGRP can elicit migraine-like headache. Medication-Overuse Headache (MOH) often has migraine features and can mimic chronic migraine. We therefore hypothesized that as in migraine, serum levels of nociceptin would be lower and CGRP serum levels higher in MOH patients compared with those in healthy volunteers. We hypothesized that the serum levels would normalize after detoxification.

METHODS: Seventeen MOH patients, hereof 70.6% with chronic migraine and MOH, and 30 sex and age matched headache-free controls were included. MOH patients underwent a 2-month outpatient detoxification program and after 6 months, 10 patients and 19 controls were retested. Blood samples were analyzed blinded.

RESULTS: We found no differences in the levels of nociceptin and CGRP between MOH patients and controls (P = 0.65 and P = 0.59). The mean headache frequency reduction was 43% and 70% of patients reverted to episodic headache after 6 months, but the levels of nociceptin and CGRP were unchanged (P = 0.71 and P = 0.82).

CONCLUSION: In contrast to previous findings in migraine patients, we found normal serum levels of nociceptin and CGRP in MOH patients. Thus, we find no evidence that the increased headache frequency of MOH patients could be caused by altered nociceptin and CGRP levels. This underlines the importance of identifying medication overuse in chronic headache and treating the MOH.

OriginalsprogEngelsk
TidsskriftActa Neurologica Scandinavica
Vol/bind139
Udgave nummer3
Sider (fra-til)269-275
Antal sider7
ISSN0001-6314
DOI
StatusUdgivet - 1 mar. 2019

ID: 56704125