Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Circulating nociceptin and CGRP in medication-overuse headache

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Absolute risk of ischemic and hemorrhagic stroke in Danish women using oral contraceptives

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Six generations of CHMP2B-mediated Frontotemporal Dementia: Clinical features, predictive testing, progression, and survival

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Stroke admissions and revascularization treatments in Denmark during COVID-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Impaired neck motor control in chronic whiplash and tension-type headache

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Neutrophil-to-lymphocyte ratio and CRP as biomarkers in multiple sclerosis: A systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Reply to 'Paracetamol use in pregnancy - neglecting context promotes misinterpretation'

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Spontan lavtrykshovedpine kan forveksles med traumatisk subduralt hæmatom

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Patient-Centered Treatment of Chronic Migraine With Medication Overuse: More Is Not Always Better

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Experimental evidence of a functional relationship within the brainstem trigeminocervical complex in humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Previous studies found low serum levels of nociceptin in migraine patients but high serum levels of calcitonin gene-related peptide (CGRP). CGRP can elicit migraine-like headache. Medication-Overuse Headache (MOH) often has migraine features and can mimic chronic migraine. We therefore hypothesized that as in migraine, serum levels of nociceptin would be lower and CGRP serum levels higher in MOH patients compared with those in healthy volunteers. We hypothesized that the serum levels would normalize after detoxification.

METHODS: Seventeen MOH patients, hereof 70.6% with chronic migraine and MOH, and 30 sex and age matched headache-free controls were included. MOH patients underwent a 2-month outpatient detoxification program and after 6 months, 10 patients and 19 controls were retested. Blood samples were analyzed blinded.

RESULTS: We found no differences in the levels of nociceptin and CGRP between MOH patients and controls (P = 0.65 and P = 0.59). The mean headache frequency reduction was 43% and 70% of patients reverted to episodic headache after 6 months, but the levels of nociceptin and CGRP were unchanged (P = 0.71 and P = 0.82).

CONCLUSION: In contrast to previous findings in migraine patients, we found normal serum levels of nociceptin and CGRP in MOH patients. Thus, we find no evidence that the increased headache frequency of MOH patients could be caused by altered nociceptin and CGRP levels. This underlines the importance of identifying medication overuse in chronic headache and treating the MOH.

OriginalsprogEngelsk
TidsskriftActa Neurologica Scandinavica
Vol/bind139
Udgave nummer3
Sider (fra-til)269-275
Antal sider7
ISSN0001-6314
DOI
StatusUdgivet - 1 mar. 2019

ID: 56704125