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Circadian, Week-to-Week, and Physical Exercise-Induced Variation of Serum Microfibrillar-Associated Protein 4

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Sækmose, SG, Holst, R, Lottenburger, T, Ytting, H, Nielsen, HJ, Junker, P, Schlosser, A & Sorensen, GL 2021, 'Circadian, Week-to-Week, and Physical Exercise-Induced Variation of Serum Microfibrillar-Associated Protein 4', Biomarker Insights, bind 16, 11772719211016359, s. 1-6. https://doi.org/10.1177/11772719211016359

APA

Sækmose, S. G., Holst, R., Lottenburger, T., Ytting, H., Nielsen, H. J., Junker, P., Schlosser, A., & Sorensen, G. L. (2021). Circadian, Week-to-Week, and Physical Exercise-Induced Variation of Serum Microfibrillar-Associated Protein 4. Biomarker Insights, 16, 1-6. [11772719211016359]. https://doi.org/10.1177/11772719211016359

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Author

Sækmose, Susanne Gjørup ; Holst, René ; Lottenburger, Tine ; Ytting, Henriette ; Nielsen, Hans Jørgen ; Junker, Peter ; Schlosser, Anders ; Sorensen, Grith Lykke. / Circadian, Week-to-Week, and Physical Exercise-Induced Variation of Serum Microfibrillar-Associated Protein 4. I: Biomarker Insights. 2021 ; Bind 16. s. 1-6.

Bibtex

@article{78e4f714133b46d6b5433381bffab6cd,
title = "Circadian, Week-to-Week, and Physical Exercise-Induced Variation of Serum Microfibrillar-Associated Protein 4",
abstract = "Serum microfibrillar-associated protein 4 (sMFAP4) has been investigated as a biomarker for various diseases and is demonstrated to show significant gradual increase with severity of liver fibrosis. Ideal biomarkers used for disease diagnosis or prognosis should display deviating levels in affected individuals only and be robust to factors unrelated to the disease. Here we show the impact of normal physiological variation of sMFAP4 by characterizing the circadian variation, week-to-week variation, and physical exercise-induced levels. Serum samples from 3 groups of healthy volunteers were drawn: 7 times during a 24-hour period, 5 times during a 3-week period, and before and after a standardized physical exercise challenge. sMFAP4 was determined by AlphaLISA. Statistical analysis was performed using mixed effects modeling of repeated measurements. Circadian variation of sMFAP4 was demonstrated, with time of peak and nadir values depending on age and gender. For males, the peak values were observed during nighttime whereas for females, peak values were observed in the morning. Individual sMFAP4 levels remained stable over a period of 3 weeks and physical exercise inferred a mild negative influence. In conclusion, the circadian sMFAP4 variation was significant, and the levels could be influenced by physical activity. However, these variations were of limited magnitude relative to previously observed disease-induced levels in support of the biomarker potential of sMFAP4.",
keywords = "biomarker, Constitutional level variation, MFAP4, Serum",
author = "S{\ae}kmose, {Susanne Gj{\o}rup} and Ren{\'e} Holst and Tine Lottenburger and Henriette Ytting and Nielsen, {Hans J{\o}rgen} and Peter Junker and Anders Schlosser and Sorensen, {Grith Lykke}",
note = "{\textcopyright} The Author(s) 2021.",
year = "2021",
month = may,
day = "14",
doi = "10.1177/11772719211016359",
language = "English",
volume = "16",
pages = "1--6",
journal = "Biomarker Insights",
issn = "1177-2719",
publisher = "Libertas Academica Ltd",

}

RIS

TY - JOUR

T1 - Circadian, Week-to-Week, and Physical Exercise-Induced Variation of Serum Microfibrillar-Associated Protein 4

AU - Sækmose, Susanne Gjørup

AU - Holst, René

AU - Lottenburger, Tine

AU - Ytting, Henriette

AU - Nielsen, Hans Jørgen

AU - Junker, Peter

AU - Schlosser, Anders

AU - Sorensen, Grith Lykke

N1 - © The Author(s) 2021.

PY - 2021/5/14

Y1 - 2021/5/14

N2 - Serum microfibrillar-associated protein 4 (sMFAP4) has been investigated as a biomarker for various diseases and is demonstrated to show significant gradual increase with severity of liver fibrosis. Ideal biomarkers used for disease diagnosis or prognosis should display deviating levels in affected individuals only and be robust to factors unrelated to the disease. Here we show the impact of normal physiological variation of sMFAP4 by characterizing the circadian variation, week-to-week variation, and physical exercise-induced levels. Serum samples from 3 groups of healthy volunteers were drawn: 7 times during a 24-hour period, 5 times during a 3-week period, and before and after a standardized physical exercise challenge. sMFAP4 was determined by AlphaLISA. Statistical analysis was performed using mixed effects modeling of repeated measurements. Circadian variation of sMFAP4 was demonstrated, with time of peak and nadir values depending on age and gender. For males, the peak values were observed during nighttime whereas for females, peak values were observed in the morning. Individual sMFAP4 levels remained stable over a period of 3 weeks and physical exercise inferred a mild negative influence. In conclusion, the circadian sMFAP4 variation was significant, and the levels could be influenced by physical activity. However, these variations were of limited magnitude relative to previously observed disease-induced levels in support of the biomarker potential of sMFAP4.

AB - Serum microfibrillar-associated protein 4 (sMFAP4) has been investigated as a biomarker for various diseases and is demonstrated to show significant gradual increase with severity of liver fibrosis. Ideal biomarkers used for disease diagnosis or prognosis should display deviating levels in affected individuals only and be robust to factors unrelated to the disease. Here we show the impact of normal physiological variation of sMFAP4 by characterizing the circadian variation, week-to-week variation, and physical exercise-induced levels. Serum samples from 3 groups of healthy volunteers were drawn: 7 times during a 24-hour period, 5 times during a 3-week period, and before and after a standardized physical exercise challenge. sMFAP4 was determined by AlphaLISA. Statistical analysis was performed using mixed effects modeling of repeated measurements. Circadian variation of sMFAP4 was demonstrated, with time of peak and nadir values depending on age and gender. For males, the peak values were observed during nighttime whereas for females, peak values were observed in the morning. Individual sMFAP4 levels remained stable over a period of 3 weeks and physical exercise inferred a mild negative influence. In conclusion, the circadian sMFAP4 variation was significant, and the levels could be influenced by physical activity. However, these variations were of limited magnitude relative to previously observed disease-induced levels in support of the biomarker potential of sMFAP4.

KW - biomarker

KW - Constitutional level variation

KW - MFAP4

KW - Serum

UR - http://www.scopus.com/inward/record.url?scp=85105853064&partnerID=8YFLogxK

U2 - 10.1177/11772719211016359

DO - 10.1177/11772719211016359

M3 - Journal article

C2 - 34035648

VL - 16

SP - 1

EP - 6

JO - Biomarker Insights

JF - Biomarker Insights

SN - 1177-2719

M1 - 11772719211016359

ER -

ID: 65795793