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Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis

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@article{d28286e9bd354ae7a0c9bb9dbc811a89,
title = "Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis",
abstract = "BACKGROUND: Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development.OBJECTIVE: To investigate the chronology of IMIDs relative to psoriasis.METHODS: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230).RESULTS: Approximately 20{\%} of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95{\%} confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients.LIMITATIONS: Clinical measurements were unavailable.CONCLUSION: IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.",
author = "Andersen, {Yuki M F} and Wu, {Jashin J} and Thyssen, {Jacob P} and Alexander Egeberg",
note = "Copyright {\circledC} 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = "12",
doi = "10.1016/j.jaad.2019.04.033",
language = "English",
volume = "81",
pages = "1283--1291",
journal = "American Academy of Dermatology. Journal",
issn = "0190-9622",
publisher = "Mosby, Inc",
number = "6",

}

RIS

TY - JOUR

T1 - Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis

AU - Andersen, Yuki M F

AU - Wu, Jashin J

AU - Thyssen, Jacob P

AU - Egeberg, Alexander

N1 - Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

PY - 2019/12

Y1 - 2019/12

N2 - BACKGROUND: Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development.OBJECTIVE: To investigate the chronology of IMIDs relative to psoriasis.METHODS: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230).RESULTS: Approximately 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95% confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients.LIMITATIONS: Clinical measurements were unavailable.CONCLUSION: IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.

AB - BACKGROUND: Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development.OBJECTIVE: To investigate the chronology of IMIDs relative to psoriasis.METHODS: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230).RESULTS: Approximately 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95% confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients.LIMITATIONS: Clinical measurements were unavailable.CONCLUSION: IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.

U2 - 10.1016/j.jaad.2019.04.033

DO - 10.1016/j.jaad.2019.04.033

M3 - Journal article

VL - 81

SP - 1283

EP - 1291

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

SN - 0190-9622

IS - 6

ER -

ID: 58985984