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Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms

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@article{d4220dd99eb444ca9b1449965c22a6d6,
title = "Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms",
abstract = "BACKGROUND: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality.METHODS: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years.RESULTS: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts.CONCLUSION: Kidney impairment might contribute to the increased mortality observed in MPN patients.",
keywords = "Aged, Aged, 80 and over, Disease Progression, Female, Glomerular Filtration Rate, Humans, Incidence, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/complications, Longitudinal Studies, Male, Middle Aged, Renal Insufficiency, Chronic/complications, Retrospective Studies",
author = "Christensen, {Alexander Sidelmann} and M{\o}ller, {Jonas Bech} and Hasselbalch, {Hans Carl}",
note = "Copyright {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",
year = "2014",
month = apr,
doi = "10.1016/j.leukres.2014.01.014",
language = "English",
volume = "38",
pages = "490--5",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Pergamon",
number = "4",

}

RIS

TY - JOUR

T1 - Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms

AU - Christensen, Alexander Sidelmann

AU - Møller, Jonas Bech

AU - Hasselbalch, Hans Carl

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2014/4

Y1 - 2014/4

N2 - BACKGROUND: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality.METHODS: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years.RESULTS: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts.CONCLUSION: Kidney impairment might contribute to the increased mortality observed in MPN patients.

AB - BACKGROUND: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality.METHODS: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years.RESULTS: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts.CONCLUSION: Kidney impairment might contribute to the increased mortality observed in MPN patients.

KW - Aged

KW - Aged, 80 and over

KW - Disease Progression

KW - Female

KW - Glomerular Filtration Rate

KW - Humans

KW - Incidence

KW - Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/complications

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Renal Insufficiency, Chronic/complications

KW - Retrospective Studies

U2 - 10.1016/j.leukres.2014.01.014

DO - 10.1016/j.leukres.2014.01.014

M3 - Journal article

C2 - 24630365

VL - 38

SP - 490

EP - 495

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 4

ER -

ID: 55097195