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Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in Hepatocyte Nuclear Factor 1-Alpha Mutation Carriers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Tocilizumab and soluble interleukin-6 receptor in JAK2V617F somatic mutation and myeloproliferative neoplasm

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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BACKGROUND: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality.

METHODS: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years.

RESULTS: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts.

CONCLUSION: Kidney impairment might contribute to the increased mortality observed in MPN patients.

Bidragets oversatte titelKronisk nyresygdom i patienter med Philidelphia-negative kroniske myeloproliferative neoplasmer
OriginalsprogEngelsk
TidsskriftLeukemia Research
Vol/bind38
Udgave nummer4
Sider (fra-til)490-5
Antal sider6
ISSN0145-2126
DOI
StatusUdgivet - apr. 2014

ID: 55097195