Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms

Bidragets oversatte titel: Kronisk nyresygdom i patienter med Philidelphia-negative kroniske myeloproliferative neoplasmer

Alexander Sidelmann Christensen, Jonas Bech Møller, Hans Carl Hasselbalch

    39 Citationer (Scopus)

    Abstract

    BACKGROUND: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality.

    METHODS: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years.

    RESULTS: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts.

    CONCLUSION: Kidney impairment might contribute to the increased mortality observed in MPN patients.

    Bidragets oversatte titelKronisk nyresygdom i patienter med Philidelphia-negative kroniske myeloproliferative neoplasmer
    OriginalsprogEngelsk
    TidsskriftLeukemia Research
    Vol/bind38
    Udgave nummer4
    Sider (fra-til)490-5
    Antal sider6
    ISSN0145-2126
    DOI
    StatusUdgivet - apr. 2014

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