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E-pub ahead of print

Chronic cough in individuals with COPD: a population-based cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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Vis graf over relationer

BACKGROUND: The role and impact of chronic cough in individuals with COPD has not been described in the general population. We hypothesised that comorbid chronic cough is a marker of disease severity in individuals with COPD.

METHODS: We identified individuals with COPD and chronic cough, and recorded respiratory symptoms, healthcare utilizations, lung function, and inflammatory biomarkers in blood in a nested cohort of 43,271 adults from the Copenhagen General Population Study.

RESULTS: Among 43,271 individuals from the general population, 8181 (19%) suffered from COPD, of whom 796 (10%) had chronic cough. Individuals with COPD and chronic cough had a Leicester Cough Questionnaire median total score of 17.7 (25th-75th percentiles: 16.0-18.9), corresponding to 5.9 (5.3-6.3) for the physical domain, 5.6 (4.9-6.3) for the psychological domain, and 6.3 (5.8-6.8) for the social domain. Among individuals with COPD, those with chronic cough versus those without had more often sputum production (60% versus 8%), wheezing (46% versus 14%), dyspnoea (66% versus 38%), chest pain/tightness (9% versus 4%), night-time dyspnoea (8% versus 3%), episodes of acute bronchitis/pneumonias in the last 10 years (45% versus 25%), and general practitioner visits in the past 12 months (53% versus 37%). Furthermore, these individuals had lower FEV1 % of predicted (81% versus 89%), FEV1/FVC (0.64 versus 0.66), as well as higher levels of high-sensitive C-reactive protein, fibrinogen, leukocytes, neutrophils, eosinophils and IgE in blood.

CONCLUSION: Comorbid chronic cough in individuals with COPD is associated with a more severe disease in terms of more respiratory symptoms and healthcare utilizations, lower lung function, and increased inflammation in blood.

OriginalsprogEngelsk
TidsskriftChest
ISSN0012-3692
DOI
StatusE-pub ahead of print - 24 jan. 2020

Bibliografisk note

Copyright © 2020. Published by Elsevier Inc.

ID: 59306257