Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Chromosome errors in human eggs shape natural fertility over reproductive life span

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Deep sleep drives brain fluid oscillations

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Suicide-turning the tide

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Analysis of shared heritability in common disorders of the brain

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.

OriginalsprogEngelsk
TidsskriftScience
Vol/bind365
Udgave nummer6460
Sider (fra-til)1466-1469
Antal sider4
ISSN0036-8075
DOI
StatusUdgivet - 27 sep. 2019

Bibliografisk note

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

ID: 58634428