Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa

O Ciofu, T J Beveridge, J Kadurugamuwa, J Walther-Rasmussen, N Høiby

Abstract

Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.

OriginalsprogEngelsk
TidsskriftThe Journal of antimicrobial chemotherapy
Vol/bind45
Udgave nummer1
Sider (fra-til)9-13
Antal sider5
ISSN0305-7453
DOI
StatusUdgivet - jan. 2000
Udgivet eksterntJa

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