Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa

O Ciofu; T J Beveridge; J Kadurugamuwa; J Walther-Rasmussen; N Høiby

doi:10.1093/jac/45.1.9

Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa

O Ciofu, T J Beveridge, J Kadurugamuwa, J Walther-Rasmussen, N Høiby

242 Citationer (Scopus)

Abstract

Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.

Originalsprog	Engelsk
Tidsskrift	The Journal of antimicrobial chemotherapy
Vol/bind	45
Udgave nummer	1
Sider (fra-til)	9-13
Antal sider	5
ISSN	0305-7453
DOI	https://doi.org/10.1093/jac/45.1.9
Status	Udgivet - jan. 2000
Udgivet eksternt	Ja

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10.1093/jac/45.1.9

Citationsformater

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title = "Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa",

abstract = "Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.",

keywords = "Cell Membrane/enzymology, Chromosomes, Bacterial/genetics, Cystic Fibrosis/microbiology, Humans, Lung/microbiology, Pseudomonas aeruginosa/enzymology, beta-Lactam Resistance, beta-Lactamases/genetics",

author = "O Ciofu and Beveridge, {T J} and J Kadurugamuwa and J Walther-Rasmussen and N H{\o}iby",

year = "2000",

month = jan,

doi = "10.1093/jac/45.1.9",

language = "English",

volume = "45",

pages = "9--13",

journal = "The Journal of antimicrobial chemotherapy",

issn = "0305-7453",

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TY - JOUR

T1 - Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa

AU - Ciofu, O

AU - Beveridge, T J

AU - Kadurugamuwa, J

AU - Walther-Rasmussen, J

AU - Høiby, N

PY - 2000/1

Y1 - 2000/1

N2 - Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.

AB - Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.

KW - Cell Membrane/enzymology

KW - Chromosomes, Bacterial/genetics

KW - Cystic Fibrosis/microbiology

KW - Humans

KW - Lung/microbiology

KW - Pseudomonas aeruginosa/enzymology

KW - beta-Lactam Resistance

KW - beta-Lactamases/genetics

U2 - 10.1093/jac/45.1.9

DO - 10.1093/jac/45.1.9

M3 - Journal article

C2 - 10629007

SN - 0305-7453

VL - 45

SP - 9

EP - 13

JO - The Journal of antimicrobial chemotherapy

JF - The Journal of antimicrobial chemotherapy

IS - 1

ER -

Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa

Abstract

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