Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines

Medicin og biovidenskab

• Razoxane 100%
• Topoisomerase II Inhibitors 80%
• Cricetulus 60%
• Ovary 49%
• Type II DNA Topoisomerase 39%
• Mutation 31%
• Etoposide 27%
• Dexrazoxane 20%
• Poisons 16%
• 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione 8%
• Enzymes 7%
• Complementary DNA 6%
• Amsacrine 6%
• Adenosine Triphosphate 6%
• Single-Stranded DNA Breaks 5%
• DNA Breaks 5%
• Excipients 5%
• Site-Directed Mutagenesis 4%
• Pharmaceutical Preparations 3%
• Yeasts 3%
• Protein Isoforms 3%
• Temperature 3%
• Western Blotting 2%
• Cell Line 2%
• Proteins 1%