@article{3238539063ef11df9344000ea68e967b,
title = "Childhood motor coordination and adult schizophrenia spectrum disorders",
abstract = "OBJECTIVE: The authors examined whether motor coordination difficulties assessed in childhood predict later adult schizophrenia spectrum outcomes. METHOD: A standardized childhood neurological examination was administered to a sample of 265 Danish children in 1972, when participants were 10-13 years old. Adult diagnostic information was available for 244 members of the sample. Participants fell into three groups: children whose mothers or fathers had a psychiatric hospital diagnosis of schizophrenia (N=94); children who had at least one parent with a psychiatric record of hospitalization for a nonpsychotic disorder (N=84); and children with no parental records of psychiatric hospitalization (N=66). Psychiatric outcomes of the offspring were assessed through psychiatric interviews in 1992 when participants were 31-33 years of age, as well as through a scan of national psychiatric registers completed in May 2007. RESULTS: Children who later developed a schizophrenia spectrum disorder (N=32) displayed significantly higher scores on a scale of coordination deficits compared with those who did not develop a mental illness in this category (N=133). CONCLUSIONS: Results from this study provide further support for the neurodevelopmental hypothesis of schizophrenia and underscore the potential role of cerebellar and/or basal ganglia abnormalities in the etiology and pathophysiology of schizophrenia.",
author = "Jason Schiffman and S{\o}rensen, {Holger Jelling} and Justin Maeda and Mortensen, {Erik L} and Jeff Victoroff and Kentaro Hayashi and Michelsen, {Niels M} and Morten Ekstr{\o}m and Sarnoff Mednick",
note = "Keywords: Adult; Basal Ganglia; Cerebellum; Child; Child of Impaired Parents; Denmark; Fathers; Female; Hospitalization; Hospitals, Psychiatric; Humans; Male; Mental Disorders; Mothers; Motor Skills Disorders; Neurologic Examination; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology",
year = "2009",
doi = "10.1176/appi.ajp.2009.08091400",
language = "English",
volume = "166",
pages = "1041--7",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Publishing, Inc",
number = "9",
}