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Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder

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Schiffman, Jason ; Mittal, Vijay ; Kline, Emily ; Mortensen, Erik L ; Michelsen, Niels ; Ekstrøm, Morten ; Millman, Zachary B ; Mednick, Sarnoff A ; Sørensen, Holger J. / Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder. I: Development and Psychopathology. 2015 ; Bind 27, Nr. 4 Pt 1. s. 1323-30.

Bibtex

@article{ba2c0d0307bd443e8c7d92b4f6afe0a4,
title = "Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder",
abstract = "Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective-psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10-13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective-psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, χ2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective-psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective-psychosis-spectrum disorders.",
author = "Jason Schiffman and Vijay Mittal and Emily Kline and Mortensen, {Erik L} and Niels Michelsen and Morten Ekstr{\o}m and Millman, {Zachary B} and Mednick, {Sarnoff A} and S{\o}rensen, {Holger J}",
year = "2015",
month = nov,
doi = "10.1017/S0954579414001436",
language = "English",
volume = "27",
pages = "1323--30",
journal = "Development and Psychopathology",
issn = "0954-5794",
publisher = "Cambridge University Press",
number = "4 Pt 1",

}

RIS

TY - JOUR

T1 - Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder

AU - Schiffman, Jason

AU - Mittal, Vijay

AU - Kline, Emily

AU - Mortensen, Erik L

AU - Michelsen, Niels

AU - Ekstrøm, Morten

AU - Millman, Zachary B

AU - Mednick, Sarnoff A

AU - Sørensen, Holger J

PY - 2015/11

Y1 - 2015/11

N2 - Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective-psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10-13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective-psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, χ2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective-psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective-psychosis-spectrum disorders.

AB - Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective-psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10-13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective-psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, χ2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective-psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective-psychosis-spectrum disorders.

U2 - 10.1017/S0954579414001436

DO - 10.1017/S0954579414001436

M3 - Journal article

C2 - 26439077

VL - 27

SP - 1323

EP - 1330

JO - Development and Psychopathology

JF - Development and Psychopathology

SN - 0954-5794

IS - 4 Pt 1

ER -

ID: 46196464