Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder

Jason Schiffman, Vijay Mittal, Emily Kline, Erik L Mortensen, Niels Michelsen, Morten Ekstrøm, Zachary B Millman, Sarnoff A Mednick, Holger J Sørensen

9 Citationer (Scopus)


Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective-psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10-13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective-psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, χ2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective-psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective-psychosis-spectrum disorders.

TidsskriftDevelopment and Psychopathology
Udgave nummer4 Pt 1
Sider (fra-til)1323-30
Antal sider8
StatusUdgivet - nov. 2015


Dyk ned i forskningsemnerne om 'Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder'. Sammen danner de et unikt fingeraftryk.