Childhood body size and associations with prostate and endometrial cancer risks and adult body size (Ph.D)

Dansk: Prostata og livmoder carcinogenese er relateret til tidlig kropsstørrelse, hvilket indikerer, at disse sygdomme kunne opstå tidligt i livet. Selvom disse sammenhænge kunne forklares via tracking, er det ikke sandsynligt, at kropsstørrelse i voksenlivet fuldstændigt forklarer disse resultater. Overvægtige børn har en stor risiko for at være overvægtige som voksne, men sammenhængene er svage i voksenalderen, hvor mange kræftformer opstår. Samlet set fremhæver disse resultater, at udover at kropsstørrelse i barndommen indikerer en risiko for senere at udvikle prostata- og livmoder-kræft, så er barndommen en periode hvor mekanistiske undersøgelser af disse sammenhænge skal fokusere.
Engelsk: Prostate and endometrial cardinogenesis is linked to early life body size, suggesting that these diseases have early origins. Even though these associations may operate through adult body size, it is not likely that adult size entirely explains these findings. Overweight children have a high risk of being overweight as adults, however, these associations are weak at late adulthood, when most cancer forms emerge. Taken together, these findings highlight that, in addition to childhood body size indicating a risk of later prostate and endometrial cancer, childhood may be the period of time that mechanistic investigations should focus on in their search for links between body size and the risk of these cancer forms.