Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Changes in metabolism but not myocellular signaling by training with CHO-restriction in endurance athletes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Four days of bed rest increases intrinsic mitochondrial respiratory capacity in young healthy males

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. High-intensity interval training changes mitochondrial respiratory capacity differently in adipose tissue and skeletal muscle

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Resistance exercise stimulates mixed muscle protein synthesis in lean and obese young adults

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Postprandial secretion of glucagon-like peptide-1 (GLP-1) is enhanced after Roux-en-Y gastric bypass (RYGB), but the precise molecular mechanisms explaining this remain poorly understood. Plasma concentrations of bile acids (BAs) increase after RYGB, and BAs may act as molecular enhancers of GLP-1 secretion through activation of TGR5-receptors. We aimed to evaluate GLP-1 secretion after oral administration of the primary bile acid chenodeoxycholic acid (CDCA) and the secondary bile acid ursodeoxycholic acid (UDCA) (which are available for oral use) in RYGB-operated participants. Eleven participants (BMI 29.1 ± 1.2, age 37.0 ± 3.2 years, time from RYGB 32.3 ± 1.1 months, weight loss after RYGB 37.0 ± 3.1 kg) were studied in a placebo-controlled, crossover-study. On three different days, participants ingested (1) placebo (water), (2) UDCA 750 mg, (3) CDCA 1250 mg (highest recommended doses). Oral intake of CDCA increased plasma concentrations of GLP-1, C-peptide, glucagon, peptide YY, neurotensin, total bile acids, and fibroblast growth factor 19 significantly compared with placebo (all P < 0.05 for peak and positive incremental area-under-the-curve (piAUC)). All plasma hormone concentrations were unaffected by UDCA Neither UDCA nor CDCA changed glucose, cholecystokinin or glucose-dependent insulinotropic polypeptide (GIP) concentrations. In conclusion, our findings demonstrate that the primary bile acid chenodeoxycholic acid is able to enhance secretion of gut hormones when administered orally in RYGB-operated patients-even in the absence of nutrients.

OriginalsprogEngelsk
TidsskriftPhysiological Reports
Vol/bind5
Udgave nummer3
DOI
StatusUdgivet - 1 feb. 2017

ID: 49887744