Characterization of the in Vitro Effects of Glucocorticosteroids on NK Cell Activity

B. K. Pedersen; J. M. Beyer

doi:10.1111/j.1398-9995.1986.tb00303.x

Characterization of the in Vitro Effects of Glucocorticosteroids on NK Cell Activity

B. K. Pedersen^*
, J. M. Beyer

^*Corresponding author af dette arbejde

33 Citationer (Scopus)

Abstract

The NK cell activity of mononuclear cells as well as monocyte‐depleted, Percoll‐fractionated, NK cell‐enriched effector cells against K 562 target cells was inhibited by methylprednisolone (MP) and hydrocortisone (HC) in a dose‐dependent manner. The effector/target cell conjugate formation was studied in a single cell agarose assay, and it was shown that MP and HC partly inhibited the NK cell activity by inhibition of the adhesion of effector cells to target.

Originalsprog	Engelsk
Tidsskrift	Allergy
Vol/bind	41
Udgave nummer	3
Sider (fra-til)	220-224
Antal sider	5
ISSN	0105-4538
DOI	https://doi.org/10.1111/j.1398-9995.1986.tb00303.x
Status	Udgivet - apr. 1986
Udgivet eksternt	Ja

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title = "Characterization of the in Vitro Effects of Glucocorticosteroids on NK Cell Activity",

abstract = "The NK cell activity of mononuclear cells as well as monocyte‐depleted, Percoll‐fractionated, NK cell‐enriched effector cells against K 562 target cells was inhibited by methylprednisolone (MP) and hydrocortisone (HC) in a dose‐dependent manner. The effector/target cell conjugate formation was studied in a single cell agarose assay, and it was shown that MP and HC partly inhibited the NK cell activity by inhibition of the adhesion of effector cells to target.",

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author = "Pedersen, \{B. K.\} and Beyer, \{J. M.\}",

year = "1986",

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TY - JOUR

T1 - Characterization of the in Vitro Effects of Glucocorticosteroids on NK Cell Activity

AU - Pedersen, B. K.

AU - Beyer, J. M.

PY - 1986/4

Y1 - 1986/4

N2 - The NK cell activity of mononuclear cells as well as monocyte‐depleted, Percoll‐fractionated, NK cell‐enriched effector cells against K 562 target cells was inhibited by methylprednisolone (MP) and hydrocortisone (HC) in a dose‐dependent manner. The effector/target cell conjugate formation was studied in a single cell agarose assay, and it was shown that MP and HC partly inhibited the NK cell activity by inhibition of the adhesion of effector cells to target.

AB - The NK cell activity of mononuclear cells as well as monocyte‐depleted, Percoll‐fractionated, NK cell‐enriched effector cells against K 562 target cells was inhibited by methylprednisolone (MP) and hydrocortisone (HC) in a dose‐dependent manner. The effector/target cell conjugate formation was studied in a single cell agarose assay, and it was shown that MP and HC partly inhibited the NK cell activity by inhibition of the adhesion of effector cells to target.

KW - hydrocortisone

KW - methylprednisolone

KW - natural killer cell activity

UR - https://www.scopus.com/pages/publications/0022466229

U2 - 10.1111/j.1398-9995.1986.tb00303.x

DO - 10.1111/j.1398-9995.1986.tb00303.x

M3 - Journal article

C2 - 2424334

AN - SCOPUS:0022466229

SN - 0105-4538

VL - 41

SP - 220

EP - 224

JO - Allergy

JF - Allergy

IS - 3

ER -

Characterization of the in Vitro Effects of Glucocorticosteroids on NK Cell Activity

Abstract

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