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Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

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@article{fb43524ae711402d8269acc6cc1de407,
title = "Characterization of na{\"i}ve, memory and effector T cells in progressive multiple sclerosis",
abstract = "We characterized na{\"i}ve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.",
keywords = "Adult, Antigens, CD, Cross-Sectional Studies, Disability Evaluation, Female, Flow Cytometry, Humans, Immunologic Factors, Immunologic Memory, Lymphocyte Activation, Male, Middle Aged, Multiple Sclerosis, Natalizumab, Statistics, Nonparametric, T-Lymphocyte Subsets, Journal Article",
author = "Nielsen, {Birgitte Romme} and Rikke Ratzer and Lars B{\"o}rnsen and {von Essen}, {Marina Rode} and Christensen, {Jeppe Romme} and Finn Sellebjerg",
note = "Copyright {\circledC} 2017 Elsevier B.V. All rights reserved.",
year = "2017",
month = "9",
day = "15",
doi = "10.1016/j.jneuroim.2017.06.001",
language = "English",
volume = "310",
pages = "17--25",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

AU - Nielsen, Birgitte Romme

AU - Ratzer, Rikke

AU - Börnsen, Lars

AU - von Essen, Marina Rode

AU - Christensen, Jeppe Romme

AU - Sellebjerg, Finn

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2017/9/15

Y1 - 2017/9/15

N2 - We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.

AB - We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.

KW - Adult

KW - Antigens, CD

KW - Cross-Sectional Studies

KW - Disability Evaluation

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Immunologic Factors

KW - Immunologic Memory

KW - Lymphocyte Activation

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis

KW - Natalizumab

KW - Statistics, Nonparametric

KW - T-Lymphocyte Subsets

KW - Journal Article

U2 - 10.1016/j.jneuroim.2017.06.001

DO - 10.1016/j.jneuroim.2017.06.001

M3 - Journal article

VL - 310

SP - 17

EP - 25

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -

ID: 52217545