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Udgivet
Characterization of naïve, memory and effector T cells in progressive multiple sclerosis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Harvard
Nielsen, BR, Ratzer, R, Börnsen, L, von Essen, MR, Christensen, JR & Sellebjerg, F 2017, 'Characterization of naïve, memory and effector T cells in progressive multiple sclerosis' Journal of Neuroimmunology, bind 310, s. 17-25. https://doi.org/10.1016/j.jneuroim.2017.06.001
APA
Nielsen, B. R., Ratzer, R., Börnsen, L., von Essen, M. R., Christensen, J. R., & Sellebjerg, F. (2017). Characterization of naïve, memory and effector T cells in progressive multiple sclerosis. Journal of Neuroimmunology, 310, 17-25. https://doi.org/10.1016/j.jneuroim.2017.06.001
CBE
Nielsen BR, Ratzer R, Börnsen L, von Essen MR, Christensen JR, Sellebjerg F. 2017. Characterization of naïve, memory and effector T cells in progressive multiple sclerosis. Journal of Neuroimmunology. 310:17-25. https://doi.org/10.1016/j.jneuroim.2017.06.001
MLA
Nielsen, Birgitte Romme o.a.. "Characterization of naïve, memory and effector T cells in progressive multiple sclerosis". Journal of Neuroimmunology. 2017, 310. 17-25. https://doi.org/10.1016/j.jneuroim.2017.06.001
Vancouver
Nielsen BR, Ratzer R, Börnsen L, von Essen MR, Christensen JR, Sellebjerg F. Characterization of naïve, memory and effector T cells in progressive multiple sclerosis. Journal of Neuroimmunology. 2017 sep 15;310:17-25. https://doi.org/10.1016/j.jneuroim.2017.06.001
Author
Bibtex
@article{fb43524ae711402d8269acc6cc1de407,
title = "Characterization of na{\"i}ve, memory and effector T cells in progressive multiple sclerosis",
abstract = "We characterized na{\"i}ve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.",
keywords = "Adult, Antigens, CD, Cross-Sectional Studies, Disability Evaluation, Female, Flow Cytometry, Humans, Immunologic Factors, Immunologic Memory, Lymphocyte Activation, Male, Middle Aged, Multiple Sclerosis, Natalizumab, Statistics, Nonparametric, T-Lymphocyte Subsets, Journal Article",
author = "Nielsen, {Birgitte Romme} and Rikke Ratzer and Lars B{\"o}rnsen and {von Essen}, {Marina Rode} and Christensen, {Jeppe Romme} and Finn Sellebjerg",
note = "Copyright {\circledC} 2017 Elsevier B.V. All rights reserved.",
year = "2017",
month = "9",
day = "15",
doi = "10.1016/j.jneuroim.2017.06.001",
language = "English",
volume = "310",
pages = "17--25",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier BV",
}
RIS
TY - JOUR
T1 - Characterization of naïve, memory and effector T cells in progressive multiple sclerosis
AU - Nielsen, Birgitte Romme
AU - Ratzer, Rikke
AU - Börnsen, Lars
AU - von Essen, Marina Rode
AU - Christensen, Jeppe Romme
AU - Sellebjerg, Finn
N1 - Copyright © 2017 Elsevier B.V. All rights reserved.
PY - 2017/9/15
Y1 - 2017/9/15
N2 - We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.
AB - We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.
KW - Adult
KW - Antigens, CD
KW - Cross-Sectional Studies
KW - Disability Evaluation
KW - Female
KW - Flow Cytometry
KW - Humans
KW - Immunologic Factors
KW - Immunologic Memory
KW - Lymphocyte Activation
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis
KW - Natalizumab
KW - Statistics, Nonparametric
KW - T-Lymphocyte Subsets
KW - Journal Article
U2 - 10.1016/j.jneuroim.2017.06.001
DO - 10.1016/j.jneuroim.2017.06.001
M3 - Journal article
VL - 310
SP - 17
EP - 25
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
ER -
ID: 52217545