Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

Birgitte Romme Nielsen, Rikke Ratzer, Lars Börnsen, Marina Rode von Essen, Jeppe Romme Christensen, Finn Sellebjerg

20 Citationer (Scopus)

Abstract

We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.

OriginalsprogEngelsk
TidsskriftJournal of Neuroimmunology
Vol/bind310
Sider (fra-til)17-25
Antal sider9
ISSN0165-5728
DOI
StatusUdgivet - 15 sep. 2017

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