Characterization of hepatitis C virus recombinants with chimeric E1/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry

Keyphrases

• Hepatitis C Virus 100%
• Recombinant 100%
• Single Amino Acid 100%
• E2 Envelope Protein 100%
• Stem Region 100%
• Genotype 1 33%
• Hepatitis C Virus Entry 33%
• Amino Acid Variation 16%
• Genetic Studies 16%
• Cell-based 16%
• Amino Acids 16%
• Inhibition Assay 16%
• Long Delay 16%
• Vaccine Development 16%
• Drug Development 16%
• Pseudoparticle 16%
• CD81 16%
• JFH1 16%
• Infectivity Titer 16%
• Core Protein 16%
• Infectious Virus Particle 16%
• Infectious Virus Production 16%
• Envelope Protein 16%
• Reverse Genetics 16%
• Infection Spread 16%
• Particle Density 16%
• Virus Envelope 16%
• Heterodimerization 16%
• Compensatory mutation 16%
• Chimeric Construct 16%
• Particle Stability 16%
• Host Cell Entry 16%
• Entry Route 16%
• Virus Viability 16%

Biochemistry, Genetics and Molecular Biology

• Amino Acids 100%
• Hepatitis C Virus 100%
• Virus Recombinant 100%
• Recombinant 50%
• Virus Infectivity 33%
• Virus Entry 33%
• Genotyping 16%
• Genetics 16%
• Titer 16%
• CD81 16%
• Virus Particle 16%
• Virus Envelope 16%
• Virus Viability 16%

Immunology and Microbiology

• Hepatitis C Virus 100%
• Recombinant Virus 100%
• Virus Infectivity 33%
• Viral Entry 33%
• Vaccine Efficacy 16%
• Host Cell 16%
• Titer 16%
• CD81 16%
• Virus Particle 16%
• Viral Envelope 16%
• Virus Viability 16%