Characterization of gastrins and their receptor in solid human gastric adenocarcinomas

28 Citationer (Scopus)

Abstract

The gastrin and the gastrin/CCK-B receptor genes are co-expressed in several carcinomas. The primary translational product, progastrin, however, is processed to several peptides of which only those that are α-amidated at their C-terminus are receptor ligands. So far, characterization of the progastrin-derived peptides in gastric cancer has not been reported. The authors therefore examined the molecular nature of gastrin and its receptor in human gastric carcinomas.
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Gastroenterology
Vol/bind48
Udgave nummer6
Sider (fra-til)688-95
Antal sider8
ISSN0036-5521
DOI
StatusUdgivet - jun. 2013

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