CharActeristics, sizing anD outcomes of stenotic, tapered, rapHe-type bicuspid aOrtic valves treated with trans-catheter device implantation: Insights the AD HOC registry

Andrea Buono; Chiara De Biase; Tommaso Fabris; Michele Bellamoli; Won-Keun Kim; Nicholas Montarello; Giuliano Costa; Andrea Zito; Mesfer Alfadhel; Ofir Koren; Simone Fezzi; Barbara Bellini; Mauro Massussi; Andrea Scotti; Lin Bai; Giulia Costa; Alessandro Mazzapicchi; Enrico Giacomin; Riccardo Gorla; Alessia Latini; Chiara Fraccaro; Lars Sondergaard; Orazio Strazzieri; Mauro Boiago; Marco Busco; Efstratios Charitos; Ady Orbach; Antonio Messina; Luca Bettari; Edoardo Navazio; Donato Antonio Paglianiti; Takashi Nagasaka; Massimo Napodano; Emmanuel Villa; Marco Angelillis; Alfonso Ielasi; Uri Landes; Nedy Brambilla; Francesco Bedogni; Antonio Mangieri; Francesco Saia; Luca Favero; Mao Chen; Marianna Adamo; Azeem Latib; Anna Sonia Petronio; Matteo Montorfano; Raj R Makkar; Darren Mylotte; Daniel J Blackman; Marco Barbanti; Ole De Backer; Didier Tchètchè; Diego Maffeo; Giuseppe Tarantini

doi:10.1016/j.ijcard.2024.132569

CharActeristics, sizing anD outcomes of stenotic, tapered, rapHe-type bicuspid aOrtic valves treated with trans-catheter device implantation: Insights the AD HOC registry

Andrea Buono, Chiara De Biase, Tommaso Fabris, Michele Bellamoli, Won-Keun Kim, Nicholas Montarello, Giuliano Costa, Andrea Zito, Mesfer Alfadhel, Ofir Koren, Simone Fezzi, Barbara Bellini, Mauro Massussi, Andrea Scotti, Lin Bai, Giulia Costa, Alessandro Mazzapicchi, Enrico Giacomin, Riccardo Gorla, Alessia LatiniChiara Fraccaro, Lars Sondergaard, Orazio Strazzieri, Mauro Boiago, Marco Busco, Efstratios Charitos, Ady Orbach, Antonio Messina, Luca Bettari, Edoardo Navazio, Donato Antonio Paglianiti, Takashi Nagasaka, Massimo Napodano, Emmanuel Villa, Marco Angelillis, Alfonso Ielasi, Uri Landes, Nedy Brambilla, Francesco Bedogni, Antonio Mangieri, Francesco Saia, Luca Favero, Mao Chen, Marianna Adamo, Azeem Latib, Anna Sonia Petronio, Matteo Montorfano, Raj R Makkar, Darren Mylotte, Daniel J Blackman, Marco Barbanti, Ole De Backer, Didier Tchètchè, Diego Maffeo, Giuseppe Tarantini^*

^*Corresponding author af dette arbejde

Afdeling for Hjertesygdomme HJE

11 Citationer (Scopus)

Abstract

BACKGROUND: Raphe-type bicuspid aortic valve (BAV) is a potential hostile scenario in trans-catheter aortic valve replacement (TAVR) due to pronounced calcium burden, possibly associated with tapered valve configuration. Trans-Catheter heart valve (THV) sizing strategy (annular vs. supra-annular) is controversial in this valve subtype.

OBJECTIVES: To describe the phenotypical characteristics of severe, tapered, raphe-type, BAV stenosis undergoing TAVR and to explore safety and efficacy of modern-generation THVs, analysing the impact of annular and supra-annular sizing strategies on short- and mid-terms outcomes.

METHODS: This is a retrospective, multicenter registry enrolling consecutive stenotic Sievers type 1 BAV treated with TAVR. Study population was divided into tapered and non-tapered configuration according to MSCT analysis. Matched comparison between annular and supra-annular sizing groups was performed in tapered population.

RESULTS: From January 2016 to June 2023, 897 patients were enrolled. Of them, 696 patients displayed a tapered configuration. Of those, 510 received a THV according to annular sizing. After propensity score matching 186 matched pairs were selected. Technical success (96.2 % vs 94.1 %, OR 1.61 [0.61-4.24], p = 0.34), 30-day device success (83.6 % in both groups, OR 1.42 [0.78-2.57], p = 0.25) and 30-day early safety (71.8 % vs 70.5 %, OR 1.07 [0.68-1.68], p = 0.78) were similar between the annular and supra-annular sizing groups; a higher post-TAVR gradient was observed in supra-annular group, although it was only 2 mmHg mean. At mid-term follow-up, the rate of clinical efficacy was 84.7 %.

CONCLUSIONS: TAVR with modern-generation devices is safe and effective for tapered raphe-type BAV, showing comparable results for annular and supra-annular sizing strategies.

Originalsprog	Engelsk
Artikelnummer	132569
Tidsskrift	International Journal of Cardiology
Vol/bind	417
ISSN	0167-5273
DOI	https://doi.org/10.1016/j.ijcard.2024.132569
Status	Udgivet - 2024

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10.1016/j.ijcard.2024.132569

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Buono, A., De Biase, C., Fabris, T., Bellamoli, M., Kim, W.-K., Montarello, N., Costa, G., Zito, A., Alfadhel, M., Koren, O., Fezzi, S., Bellini, B., Massussi, M., Scotti, A., Bai, L., Costa, G., Mazzapicchi, A., Giacomin, E., Gorla, R., ... Tarantini, G. (2024). CharActeristics, sizing anD outcomes of stenotic, tapered, rapHe-type bicuspid aOrtic valves treated with trans-catheter device implantation: Insights the AD HOC registry. International Journal of Cardiology, 417, Artikel 132569. https://doi.org/10.1016/j.ijcard.2024.132569

CharActeristics, sizing anD outcomes of stenotic, tapered, rapHe-type bicuspid aOrtic valves treated with trans-catheter device implantation: Insights the AD HOC registry. / Buono, Andrea; De Biase, Chiara; Fabris, Tommaso et al.
I: International Journal of Cardiology, Bind 417, 132569, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Buono, A, De Biase, C, Fabris, T, Bellamoli, M, Kim, W-K, Montarello, N, Costa, G, Zito, A, Alfadhel, M, Koren, O, Fezzi, S, Bellini, B, Massussi, M, Scotti, A, Bai, L, Costa, G, Mazzapicchi, A, Giacomin, E, Gorla, R, Latini, A, Fraccaro, C, Sondergaard, L, Strazzieri, O, Boiago, M, Busco, M, Charitos, E, Orbach, A, Messina, A, Bettari, L, Navazio, E, Paglianiti, DA, Nagasaka, T, Napodano, M, Villa, E, Angelillis, M, Ielasi, A, Landes, U, Brambilla, N, Bedogni, F, Mangieri, A, Saia, F, Favero, L, Chen, M, Adamo, M, Latib, A, Petronio, AS, Montorfano, M, Makkar, RR, Mylotte, D, Blackman, DJ, Barbanti, M, De Backer, O, Tchètchè, D, Maffeo, D & Tarantini, G 2024, 'CharActeristics, sizing anD outcomes of stenotic, tapered, rapHe-type bicuspid aOrtic valves treated with trans-catheter device implantation: Insights the AD HOC registry', International Journal of Cardiology, bind 417, 132569. https://doi.org/10.1016/j.ijcard.2024.132569

@article{6ea0457396b64e5391dd35bec05e8fc9,

title = "CharActeristics, sizing anD outcomes of stenotic, tapered, rapHe-type bicuspid aOrtic valves treated with trans-catheter device implantation: Insights the AD HOC registry",

abstract = "BACKGROUND: Raphe-type bicuspid aortic valve (BAV) is a potential hostile scenario in trans-catheter aortic valve replacement (TAVR) due to pronounced calcium burden, possibly associated with tapered valve configuration. Trans-Catheter heart valve (THV) sizing strategy (annular vs. supra-annular) is controversial in this valve subtype.OBJECTIVES: To describe the phenotypical characteristics of severe, tapered, raphe-type, BAV stenosis undergoing TAVR and to explore safety and efficacy of modern-generation THVs, analysing the impact of annular and supra-annular sizing strategies on short- and mid-terms outcomes.METHODS: This is a retrospective, multicenter registry enrolling consecutive stenotic Sievers type 1 BAV treated with TAVR. Study population was divided into tapered and non-tapered configuration according to MSCT analysis. Matched comparison between annular and supra-annular sizing groups was performed in tapered population.RESULTS: From January 2016 to June 2023, 897 patients were enrolled. Of them, 696 patients displayed a tapered configuration. Of those, 510 received a THV according to annular sizing. After propensity score matching 186 matched pairs were selected. Technical success (96.2 % vs 94.1 %, OR 1.61 [0.61-4.24], p = 0.34), 30-day device success (83.6 % in both groups, OR 1.42 [0.78-2.57], p = 0.25) and 30-day early safety (71.8 % vs 70.5 %, OR 1.07 [0.68-1.68], p = 0.78) were similar between the annular and supra-annular sizing groups; a higher post-TAVR gradient was observed in supra-annular group, although it was only 2 mmHg mean. At mid-term follow-up, the rate of clinical efficacy was 84.7 %.CONCLUSIONS: TAVR with modern-generation devices is safe and effective for tapered raphe-type BAV, showing comparable results for annular and supra-annular sizing strategies.",

author = "Andrea Buono and {De Biase}, Chiara and Tommaso Fabris and Michele Bellamoli and Won-Keun Kim and Nicholas Montarello and Giuliano Costa and Andrea Zito and Mesfer Alfadhel and Ofir Koren and Simone Fezzi and Barbara Bellini and Mauro Massussi and Andrea Scotti and Lin Bai and Giulia Costa and Alessandro Mazzapicchi and Enrico Giacomin and Riccardo Gorla and Alessia Latini and Chiara Fraccaro and Lars Sondergaard and Orazio Strazzieri and Mauro Boiago and Marco Busco and Efstratios Charitos and Ady Orbach and Antonio Messina and Luca Bettari and Edoardo Navazio and Paglianiti, {Donato Antonio} and Takashi Nagasaka and Massimo Napodano and Emmanuel Villa and Marco Angelillis and Alfonso Ielasi and Uri Landes and Nedy Brambilla and Francesco Bedogni and Antonio Mangieri and Francesco Saia and Luca Favero and Mao Chen and Marianna Adamo and Azeem Latib and Petronio, {Anna Sonia} and Matteo Montorfano and Makkar, {Raj R} and Darren Mylotte and Blackman, {Daniel J} and Marco Barbanti and {De Backer}, Ole and Didier Tch{\`e}tch{\`e} and Diego Maffeo and Giuseppe Tarantini",

year = "2024",

doi = "10.1016/j.ijcard.2024.132569",

language = "English",

volume = "417",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - CharActeristics, sizing anD outcomes of stenotic, tapered, rapHe-type bicuspid aOrtic valves treated with trans-catheter device implantation

T2 - Insights the AD HOC registry

AU - Buono, Andrea

AU - De Biase, Chiara

AU - Fabris, Tommaso

AU - Bellamoli, Michele

AU - Kim, Won-Keun

AU - Montarello, Nicholas

AU - Costa, Giuliano

AU - Zito, Andrea

AU - Alfadhel, Mesfer

AU - Koren, Ofir

AU - Fezzi, Simone

AU - Bellini, Barbara

AU - Massussi, Mauro

AU - Scotti, Andrea

AU - Bai, Lin

AU - Costa, Giulia

AU - Mazzapicchi, Alessandro

AU - Giacomin, Enrico

AU - Gorla, Riccardo

AU - Latini, Alessia

AU - Fraccaro, Chiara

AU - Sondergaard, Lars

AU - Strazzieri, Orazio

AU - Boiago, Mauro

AU - Busco, Marco

AU - Charitos, Efstratios

AU - Orbach, Ady

AU - Messina, Antonio

AU - Bettari, Luca

AU - Navazio, Edoardo

AU - Paglianiti, Donato Antonio

AU - Nagasaka, Takashi

AU - Napodano, Massimo

AU - Villa, Emmanuel

AU - Angelillis, Marco

AU - Ielasi, Alfonso

AU - Landes, Uri

AU - Brambilla, Nedy

AU - Bedogni, Francesco

AU - Mangieri, Antonio

AU - Saia, Francesco

AU - Favero, Luca

AU - Chen, Mao

AU - Adamo, Marianna

AU - Latib, Azeem

AU - Petronio, Anna Sonia

AU - Montorfano, Matteo

AU - Makkar, Raj R

AU - Mylotte, Darren

AU - Blackman, Daniel J

AU - Barbanti, Marco

AU - De Backer, Ole

AU - Tchètchè, Didier

AU - Maffeo, Diego

AU - Tarantini, Giuseppe

PY - 2024

Y1 - 2024

N2 - BACKGROUND: Raphe-type bicuspid aortic valve (BAV) is a potential hostile scenario in trans-catheter aortic valve replacement (TAVR) due to pronounced calcium burden, possibly associated with tapered valve configuration. Trans-Catheter heart valve (THV) sizing strategy (annular vs. supra-annular) is controversial in this valve subtype.OBJECTIVES: To describe the phenotypical characteristics of severe, tapered, raphe-type, BAV stenosis undergoing TAVR and to explore safety and efficacy of modern-generation THVs, analysing the impact of annular and supra-annular sizing strategies on short- and mid-terms outcomes.METHODS: This is a retrospective, multicenter registry enrolling consecutive stenotic Sievers type 1 BAV treated with TAVR. Study population was divided into tapered and non-tapered configuration according to MSCT analysis. Matched comparison between annular and supra-annular sizing groups was performed in tapered population.RESULTS: From January 2016 to June 2023, 897 patients were enrolled. Of them, 696 patients displayed a tapered configuration. Of those, 510 received a THV according to annular sizing. After propensity score matching 186 matched pairs were selected. Technical success (96.2 % vs 94.1 %, OR 1.61 [0.61-4.24], p = 0.34), 30-day device success (83.6 % in both groups, OR 1.42 [0.78-2.57], p = 0.25) and 30-day early safety (71.8 % vs 70.5 %, OR 1.07 [0.68-1.68], p = 0.78) were similar between the annular and supra-annular sizing groups; a higher post-TAVR gradient was observed in supra-annular group, although it was only 2 mmHg mean. At mid-term follow-up, the rate of clinical efficacy was 84.7 %.CONCLUSIONS: TAVR with modern-generation devices is safe and effective for tapered raphe-type BAV, showing comparable results for annular and supra-annular sizing strategies.

AB - BACKGROUND: Raphe-type bicuspid aortic valve (BAV) is a potential hostile scenario in trans-catheter aortic valve replacement (TAVR) due to pronounced calcium burden, possibly associated with tapered valve configuration. Trans-Catheter heart valve (THV) sizing strategy (annular vs. supra-annular) is controversial in this valve subtype.OBJECTIVES: To describe the phenotypical characteristics of severe, tapered, raphe-type, BAV stenosis undergoing TAVR and to explore safety and efficacy of modern-generation THVs, analysing the impact of annular and supra-annular sizing strategies on short- and mid-terms outcomes.METHODS: This is a retrospective, multicenter registry enrolling consecutive stenotic Sievers type 1 BAV treated with TAVR. Study population was divided into tapered and non-tapered configuration according to MSCT analysis. Matched comparison between annular and supra-annular sizing groups was performed in tapered population.RESULTS: From January 2016 to June 2023, 897 patients were enrolled. Of them, 696 patients displayed a tapered configuration. Of those, 510 received a THV according to annular sizing. After propensity score matching 186 matched pairs were selected. Technical success (96.2 % vs 94.1 %, OR 1.61 [0.61-4.24], p = 0.34), 30-day device success (83.6 % in both groups, OR 1.42 [0.78-2.57], p = 0.25) and 30-day early safety (71.8 % vs 70.5 %, OR 1.07 [0.68-1.68], p = 0.78) were similar between the annular and supra-annular sizing groups; a higher post-TAVR gradient was observed in supra-annular group, although it was only 2 mmHg mean. At mid-term follow-up, the rate of clinical efficacy was 84.7 %.CONCLUSIONS: TAVR with modern-generation devices is safe and effective for tapered raphe-type BAV, showing comparable results for annular and supra-annular sizing strategies.

UR - http://www.scopus.com/inward/record.url?scp=85204737798&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2024.132569

DO - 10.1016/j.ijcard.2024.132569

M3 - Journal article

C2 - 39303924

SN - 0167-5273

VL - 417

JO - International Journal of Cardiology

JF - International Journal of Cardiology

M1 - 132569

ER -

CharActeristics, sizing anD outcomes of stenotic, tapered, rapHe-type bicuspid aOrtic valves treated with trans-catheter device implantation: Insights the AD HOC registry

Abstract

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