TY - JOUR
T1 - Characteristics and early outcomes of patients hospitalised for COVID-19 in North Zealand, Denmark
AU - Lendorf, Maria Elisabeth
AU - Boisen, Mogens Karsbøl
AU - Kristensen, Peter Lommer
AU - Løkkegaard, Ellen Christine Leth
AU - Krog, Sebastian Moretto
AU - Brandi, Lisbet
AU - Brinth, Louise Schouborg
AU - Nolsöe, Rúna Louise Mortansdóttir
AU - Ryrsø, Camilla
AU - Eiken, Pia
AU - Bestle, Morten Heiberg
AU - Jørgensen, Inger Merete
AU - Pedersen-Bjergaard, Ulrik
AU - Lindegaard, Birgitte
AU - Christensen, Thomas Broe
AU - Fischer, Thea Kølsen
N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
PY - 2020
Y1 - 2020
N2 - INTRODUCTION: Coronavirus disease 2019 (COVID-19) is an ongoing pandemic associated with significant morbidity and mortality worldwide. Limited data are available describing the clinical presentation and outcomes of hospitalised COVID-19 patients in Europe.METHODS: This was a single-centre retrospective chart review of all patients with COVID-19 admitted to the North Zealand Hospital in Denmark between 1 March and 4 May 2020. Main outcomes include major therapeutic interventions during hospitalisation, such as invasive mechanical ventilation, as well as death.RESULTS: A total of 115 patients were included, including four infants. The median age of adults was 68 years and 40% were female. At admission, 55 (50%) patients had a fever, 29 (26%) had a respiratory rate exceeding 24 breaths/minute, and 78 (70%) received supplemental oxygen. The prevalence of co-infection was 13%. Twenty patients (18%) (median age: 64 years; 15% female) were treated in the intensive care unit. Twelve (10.4%) received invasive mechanical ventilation and three (2.6%) renal replacement therapy. Nine patients (8%) developed pulmonary embolism. Sixteen patients (14%) died. Among patients requiring mechanical ventilation (n = 12), seven (6.1%) were discharged alive, four (3.4%) died and one (0.9%) was still hospitalised.CONCLUSION: In this cohort of hospitalised COVID-19 patients, mortality was lower than in other Danish and European case series.FUNDING: none.TRIAL REGISTRATION: not relevant.
AB - INTRODUCTION: Coronavirus disease 2019 (COVID-19) is an ongoing pandemic associated with significant morbidity and mortality worldwide. Limited data are available describing the clinical presentation and outcomes of hospitalised COVID-19 patients in Europe.METHODS: This was a single-centre retrospective chart review of all patients with COVID-19 admitted to the North Zealand Hospital in Denmark between 1 March and 4 May 2020. Main outcomes include major therapeutic interventions during hospitalisation, such as invasive mechanical ventilation, as well as death.RESULTS: A total of 115 patients were included, including four infants. The median age of adults was 68 years and 40% were female. At admission, 55 (50%) patients had a fever, 29 (26%) had a respiratory rate exceeding 24 breaths/minute, and 78 (70%) received supplemental oxygen. The prevalence of co-infection was 13%. Twenty patients (18%) (median age: 64 years; 15% female) were treated in the intensive care unit. Twelve (10.4%) received invasive mechanical ventilation and three (2.6%) renal replacement therapy. Nine patients (8%) developed pulmonary embolism. Sixteen patients (14%) died. Among patients requiring mechanical ventilation (n = 12), seven (6.1%) were discharged alive, four (3.4%) died and one (0.9%) was still hospitalised.CONCLUSION: In this cohort of hospitalised COVID-19 patients, mortality was lower than in other Danish and European case series.FUNDING: none.TRIAL REGISTRATION: not relevant.
KW - Adult
KW - Aged
KW - Betacoronavirus
KW - Coronavirus Infections/epidemiology
KW - Denmark/epidemiology
KW - Female
KW - Hospitalization/trends
KW - Humans
KW - Intensive Care Units/statistics & numerical data
KW - Male
KW - Middle Aged
KW - Pandemics
KW - Pneumonia, Viral/epidemiology
KW - Prevalence
KW - Retrospective Studies
KW - COVID-19
KW - SARS-CoV-2
M3 - Journal article
C2 - 32800073
SN - 1603-9629
VL - 67
JO - Danish Medical Journal
JF - Danish Medical Journal
IS - 9
M1 - A06200428
ER -