Changes in the pattern of paracetamol use in the periconception period in a Danish cohort

Anne S Ersbøll, Mette Hedegaard, Peter Damm, Marianne Johansen, Ann Tabor, Hanne K Hegaard

    5 Citationer (Scopus)

    Abstract

    Paracetamol is the most commonly used over-the-counter drug in pregnancy. It is generally considered to be safe, but prolonged antenatal exposure has been associated with offspring short- and long-term morbidity. Our aim was to describe the pattern of paracetamol use with a focus on frequent ingestion (more than once a week), 3 months before and in early pregnancy. In this cohort, 8650 pregnant women responded to a web-based clinical questionnaire that included questions about drug use. Paracetamol was the most used drug before and in early pregnancy (35.2% and 6.5% of respondents, respectively). The proportion of frequent users decreased from 3.9% before to 0.9% in early pregnancy. Frequent paracetamol use was associated with smoking, co-morbidities, body mass index ≥25 kg/m(2) , unplanned pregnancy, no education and inability to understand Danish. A significant decrease in the proportion of women with any paracetamol use in early pregnancy was noted after access to large packs was restricted by legislation.

    OriginalsprogEngelsk
    TidsskriftActa Obstetricia et Gynecologica Scandinavica
    Vol/bind94
    Udgave nummer8
    Sider (fra-til)898-903
    Antal sider6
    ISSN0001-6349
    DOI
    StatusUdgivet - aug. 2015

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